Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P0CB42 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
C2C12 cell | ALKBH1 enhances proliferation and inhibits differentiation of C2C12 cells | Mus musculus | - |
skeletal muscle | N6-mA levels shows a steady increase, going along with a strong decrease of ALKBH1 during skeletal muscle development | Mus musculus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | ALKBH1 is critical for the myogenic differentiation of C2C12 cells. Overexpression of ALKBH1 reduces N6-mA levels, enhances proliferation and inhibits differentiation in C2C12 cells. ALKBH1 regulates a subset of genes and impairs multiple signaling required for muscle development | Mus musculus |