Literature summary for 1.14.11.51 extracted from

Diao, L.; Xie, S.; Yu, P.; Sun, Y.; Yang, F.; Tan, Y.; Tao, S.; Hou, Y.; Zheng, L.; Xiao, Z.; Zhang, Q.
N6-methyladenine demethylase ALKBH1 inhibits the differentiation of skeletal muscle (2021), Exp. Cell Res., 400, 112492 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P0CB42	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
C2C12 cell	ALKBH1 enhances proliferation and inhibits differentiation of C2C12 cells	Mus musculus	-
skeletal muscle	N6-mA levels shows a steady increase, going along with a strong decrease of ALKBH1 during skeletal muscle development	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	ALKBH1 is critical for the myogenic differentiation of C2C12 cells. Overexpression of ALKBH1 reduces N6-mA levels, enhances proliferation and inhibits differentiation in C2C12 cells. ALKBH1 regulates a subset of genes and impairs multiple signaling required for muscle development	Mus musculus

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Release 2023.1 (January 2023)