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Literature summary for 1.14.11.51 extracted from

  • Lin, Q.; Chen, J.W.; Yin, H.; Li, M.A.; Zhou, C.R.; Hao, T.F.; Pan, T.; Wu, C.; Li, Z.R.; Zhu, D.; Wang, H.F.; Huang, M.S.
    DNA N6-methyladenine involvement and regulation of hepatocellular carcinoma development (2022), Genomics, 114, 110265 .
    View publication on PubMed

Application

Application Comment Organism
medicine ALKBH1 overexpression decreases hepatocellular carcinoma cell viability, induces apoptosis, and decreases migration and invasion. 23779 gain-of-6 mA regions and 11240 loss-of-6 mA regions are differentially identified in hepatocellular carcinoma tissues. The differential gain and loss of 6 mA regions are considerably enriched in intergenic regions. 7% of the differential 6 mA modifications are associated with tumors, with 60 associated with oncogenes and 57 with tumor suppressor genes, and 17 are common to oncogenes and TSGs Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13686 bifunctional apurinic/apyrimidinic sites lyase and m6A demethylase, cf. EC 4.2.99.18
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Synonyms

Synonyms Comment Organism
ALKBH1
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Homo sapiens

General Information

General Information Comment Organism
physiological function ALKBH1 overexpression decreases hepatocellular carcinoma cell viability, induces apoptosis, and decreases migration and invasion Homo sapiens