Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q13686 | bifunctional apurinic/apyrimidinic sites lyase and m6A demethylase, cf. EC 4.2.99.18 | - |
Synonyms | Comment | Organism |
---|---|---|
ALKBH1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | knockdown of ALKBH1 inhibits adipogenic differentiation in both mesenchymal stem cells and 3T3-L1 preadipocytes, while overexpression of ALKBH1 leads to increased adipogenesis. Hypoxia-inducible factor HIF-1 signaling is a crucial downstream target of ALKBH1 activity. Depletion of ALKBH1 leads to hypermethylation of both HIF-1alpha and its downstream target GYS1 | Homo sapiens |