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Literature summary for 1.14.11.51 extracted from

  • Ouyang, L.; Su, X.; Li, W.; Tang, L.; Zhang, M.; Zhu, Y.; Xie, C.; Zhang, P.; Chen, J.; Huang, H.
    ALKBH1-demethylated DNA N6-methyladenine modification triggers vascular calcification via osteogenic reprogramming in chronic kidney disease (2021), J. Clin. Invest., 131, e146985 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine during the progression of vascular calcification in a model of chronic kidney disease, increased ALKBH1 expression is linked to decreased 6mA levels Mus musculus
medicine in patients with chronic kidney disease, leukocyte 6mA levels are significantly reduced as the severity of vascular calcification increases. Decreased 6mA demethylation results from the upregulation of ALKBH1. ALKBH1 overexpression aggravates whereas its depletion blunts vascular calcification progression and osteogenic reprogramming in vivo and in vitro Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13686
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Mus musculus P0CB42
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