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Literature summary for 1.14.11.53 extracted from

  • Zhu, C.; Yi, C.
    Switching demethylation activities between AlkB family RNA/DNA demethylases through exchange of active-site residues (2014), Angew. Chem. Int. Ed. Engl., 53, 3659-3662.
    View publication on PubMed
Search for more literature for 1.14.11.53

Protein Variants

Protein Variants Comment Organism
I209D the mutant shows decreased activity compared to the wild type enzyme Homo sapiens
I209E the mutant shows decreased activity compared to the wild type enzyme Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00166
-
 N6-methyladenine in mRNA pH and temperature not specified in the publication Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N6-methyladenine in mRNA + 2-oxoglutarate + O2 Homo sapiens
-
 adenine in mRNA + formaldehyde + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N6-methyladenine in mRNA + 2-oxoglutarate + O2
-
 Homo sapiens adenine in mRNA + formaldehyde + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
ALKBH5
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0029
-
 N6-methyladenine in mRNA pH and temperature not specified in the publication Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.75
-
 N6-methyladenine in mRNA pH and temperature not specified in the publication Homo sapiens