Literature summary for 1.14.11.54 extracted from

Woo, H.H.; Chambers, S.K.
Human ALKBH3-induced m1A demethylation increases the CSF-1 mRNA stability in breast and ovarian cancer cells (2019), Biochim. Biophys. Acta Gene Regul. Mech., 1862, 35-46 .

Search for more literature for 1.14.11.54

Application

Application	Comment	Organism
medicine	the alteration of ALKBH3 expression regulates the cytokine CSF-1 mRNA stability. Actions of cytokine CSF-1 lead to poor prognosis in ovarian and breast cancers. Demethylation of m1A by ALKBH3 increases the half-life of CSF-1 mRNA without affecting the translation efficiency. Overexpression of ALKBH3 increases CSF-1 expression and the degree of cancer cell invasiveness without affecting cell proliferation or migration	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q96Q83	-	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)