Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.11.6 extracted from

  • Thornburg, L.D.; Lai, M.T.; Wishnok, J.S.; Stubbe, J.
    A non-heme iron protein with heme tendencies: An investigation of the substrate specificity of thymine hydroxylase (1993), Biochemistry, 32, 14023-14033.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5-acetyluracil poor competitive inhibitor Rhodotorula glutinis
5-Formyluracil competitive inhibitor with respect to thymine Rhodotorula glutinis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0011
-
Fe2+
-
Rhodotorula glutinis
0.024
-
2-oxoglutarate
-
Rhodotorula glutinis
0.036
-
O2
-
Rhodotorula glutinis
0.058
-
thymine
-
Rhodotorula glutinis
0.087
-
5,6-dihydroxythymine
-
Rhodotorula glutinis
0.118
-
5-Hydroxymethyluracil
-
Rhodotorula glutinis
0.124
-
5-(2-hydroxyethyl)uracil
-
Rhodotorula glutinis
0.322
-
5-fluorouracil
-
Rhodotorula glutinis
1.3
-
1-methylthymine
-
Rhodotorula glutinis
2.34
-
5-Formyluracil
-
Rhodotorula glutinis

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ non-heme Rhodotorula glutinis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-formyluracil + 2-oxoglutarate + O2 Rhodotorula glutinis
-
5-carboxyuracil + succinate + CO2
-
?
5-hydroxymethyluracil + 2-oxoglutarate + O2 Rhodotorula glutinis
-
5-formyluracil + succinate + CO2 5-formyluracil reacts subsequently to 5-carboxyuracil ?
thymine + 2-oxoglutarate + O2 Rhodotorula glutinis stereospecific removal of the pro-S hydrogen 5-hydroxymethyluracil + succinate + CO2 5-hydroxymethyluracil reacts subsequently to 5-formyluracil ?

Organism

Organism UniProt Comment Textmining
Rhodotorula glutinis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rhodotorula glutinis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-methylthymine + 2-oxoglutarate + O2
-
Rhodotorula glutinis 1-methyl-5-(hydroxymethyl)uracil + thymine + formaldehyde + succinate + CO2
-
?
5,6-dihydrothymine + 2-oxoglutarate + O2
-
Rhodotorula glutinis 5,6-dihydro-5-(hydroxymethyl)uracil + succinate + CO2
-
?
5,6-dihydroxythymine + 2-oxoglutarate + O2
-
Rhodotorula glutinis 5,6-dihydro-5-(hydroxymethyl)uracil + succinate + CO2
-
r
5-(2-hydroxyethyl)uracil + 2-oxoglutarate + O2
-
Rhodotorula glutinis 5-(1,2-dihydroxyethyl)uracil + succinate + CO2
-
?
5-(methylthio)uracil + 2-oxoglutarate + O2
-
Rhodotorula glutinis 5-(methylsulfonyl)uracil + 5-(methylsulfinyl)uracil + succinate + CO2
-
?
5-fluorouracil + 2-oxoglutarate + O2
-
Rhodotorula glutinis ? + succinate + CO2
-
?
5-formyluracil + 2-oxoglutarate + O2
-
Rhodotorula glutinis 5-carboxyuracil + succinate + CO2
-
?
5-formyluracil + 2-oxoglutarate + O2 5-formyluracil reacts subsequently to 5-carboxyuracil Rhodotorula glutinis 5-carboxyuracil + succinate + CO2
-
?
5-hydroxymethyluracil + 2-oxoglutarate + O2
-
Rhodotorula glutinis 5-formyluracil + succinate + CO2
-
?
5-hydroxymethyluracil + 2-oxoglutarate + O2
-
Rhodotorula glutinis 5-formyluracil + succinate + CO2 5-formyluracil reacts subsequently to 5-carboxyuracil ?
5-vinyluracil + 2-oxoglutarate + O2
-
Rhodotorula glutinis 5-(1,2-dihydroxyethyl)uracil + succinate + CO2
-
?
thymine + 2-oxoglutarate + O2 stereospecific removal of the pro-S hydrogen Rhodotorula glutinis 5-hydroxymethyluracil + succinate + CO2 5-hydroxymethyluracil reacts subsequently to 5-formyluracil ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.83
-
5-acetyluracil
-
Rhodotorula glutinis
1.39
-
5-Formyluracil with respect to thymine Rhodotorula glutinis