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Literature summary for 1.14.11.6 extracted from

  • Smiley, J.A.; Kundracik, M.; Landfried, D.A.; Barnes, V.R., Sr.; Axhemi, A.A.
    Genes of the thymidine salvage pathway: Thymine-7-hydroxylase from a Rhodotorula glutinis cDNA library and iso-orotate decarboxylase from Neurospora crassa (2005), Biochim. Biophys. Acta, 1723, 256-264.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3)Gold Rhodotorula glutinis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37000
-
calculated from deduced amino acid sequence Rhodotorula glutinis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thymine + 2-oxoglutarate + 2 O2 Rhodotorula glutinis conversion of thymine to uracil uracil-5-carboxylate + succinate + CO2 + H2O three step reaction with 5-hydroxymethyluracil and 5-formyluracil as intermediate products ?

Organism

Organism UniProt Comment Textmining
Rhodotorula glutinis Q66Q78 strain ATCC 2527
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thymine + 2-oxoglutarate + 2 O2
-
Rhodotorula glutinis uracil-5-carboxylate + succinate + CO2 + H2O three step reaction with 5-hydroxymethyluracil and 5-formyluracil as intermediate products ?
thymine + 2-oxoglutarate + 2 O2 conversion of thymine to uracil Rhodotorula glutinis uracil-5-carboxylate + succinate + CO2 + H2O three step reaction with 5-hydroxymethyluracil and 5-formyluracil as intermediate products ?