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Literature summary for 1.14.11.60 extracted from

  • Tsai, H.H.; Rodriguez-Celma, J.; Lan, P.; Wu, Y.C.; Velez-Bermudez, I.C.; Schmidt, W.
    Scopoletin 8-hydroxylase-mediated fraxetin production is crucial for iron mobilization (2018), Plant Physiol., 177, 194-207 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
scopoletin + 2-oxoglutarate + O2 Arabidopsis thaliana the enzyme participates in Fe acquisition by mediating the biosynthesis of fraxetin (7,8-dihydroxy-6-methoxycoumarin), a coumarin derived from the scopoletin pathway fraxetin + succinate + CO2
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 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q9LE86
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
scopoletin + 2-oxoglutarate + O2
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 Arabidopsis thaliana fraxetin + succinate + CO2
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 ?
scopoletin + 2-oxoglutarate + O2 the enzyme participates in Fe acquisition by mediating the biosynthesis of fraxetin (7,8-dihydroxy-6-methoxycoumarin), a coumarin derived from the scopoletin pathway Arabidopsis thaliana fraxetin + succinate + CO2
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 ?

Synonyms

Synonyms Comment Organism
At3g12900
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 Arabidopsis thaliana
S8H
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 Arabidopsis thaliana

Expression

Organism Comment Expression
Arabidopsis thaliana the enzyme is highly induced in roots of Fe-deficient plants both at the transcript and protein levels up

General Information

General Information Comment Organism
malfunction mutants defective in the expression of S8H show increased sensitivity to growth on pH 7.0 media supplemented with an immobile source of Fe and reduced secretion of fraxetin. Transgenic lines overexpressing S8H exhibit an opposite phenotype. Supplementing the media containing immobile Fe with fraxetin partially rescues the s8h mutants Arabidopsis thaliana
metabolism the enzyme participates in Fe acquisition by mediating the biosynthesis of fraxetin (7,8-dihydroxy-6-methoxycoumarin), a coumarin derived from the scopoletin pathway. Fraxetin secretion is a decisive factor for calcicole-calcifuge behavior (i.e. the ability/inability to thrive on alkaline soils) of plants Arabidopsis thaliana
physiological function the enzyme participates in Fe acquisition by mediating the biosynthesis of fraxetin (7,8-dihydroxy-6-methoxycoumarin), a coumarin derived from the scopoletin pathway. Fraxetin secretion is a decisive factor for calcicole-calcifuge behavior (i.e. the ability/inability to thrive on alkaline soils) of plants Arabidopsis thaliana