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Literature summary for 1.14.11.65 extracted from

  • Metzger, E.; Wissmann, M.; Yin, N.; Muller, J.M.; Schneider, R.; Peters, A.H.; Gunther, T.; Buettner, R.; Schule, R.
    LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription (2005), Nature, 437, 436-439.
    View publication on PubMed
Search for more literature for 1.14.11.65

Inhibitors

Inhibitors Comment Organism Structure
Pargyline
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein 6-N,6-N-dimethyl-L-lysine + 2-oxoglutarate + O2 Homo sapiens LSD1 relieves repressive histone marks by demethylation of histone H3 at lysine 9, thereby leading to derepression of androgen receptor target genes protein 6-N-methyl-L-lysine + succinate + formaldehyde + CO2
-
 ?
protein 6-N-methyl-L-lysine + 2-oxoglutarate + O2 Homo sapiens LSD1 relieves repressive histone marks by demethylation of histone H3 at lysine 9, thereby leading to derepression of androgen receptor target genes protein L-lysine + succinate + formaldehyde + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
prostate gland lysine-specific demethylase 1 colocalizes with androgen receptor Homo sapiens
-
prostate tumour cell lysine-specific demethylase 1 colocalizes with androgen receptor Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protein 6-N,6-N-dimethyl-L-lysine + 2-oxoglutarate + O2 LSD1 relieves repressive histone marks by demethylation of histone H3 at lysine 9, thereby leading to derepression of androgen receptor target genes Homo sapiens protein 6-N-methyl-L-lysine + succinate + formaldehyde + CO2
-
 ?
protein 6-N-methyl-L-lysine + 2-oxoglutarate + O2 LSD1 relieves repressive histone marks by demethylation of histone H3 at lysine 9, thereby leading to derepression of androgen receptor target genes Homo sapiens protein L-lysine + succinate + formaldehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
BHC110
-
 Homo sapiens
LSD1
-
 Homo sapiens
lysine-specific demethylase 1
-
 Homo sapiens
[histone-H3]-lysine-4-demethylase
-
 Homo sapiens