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Literature summary for 1.14.11.65 extracted from

  • Perillo, B.; Ombra, M.; Bertoni, A.; Cuozzo, C.; Sacchetti, S.; Sasso, A.; Chiariotti, L.; Malorni, A.; Abbondanza, C.; Avvedimento, E.
    DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression (2008), Science, 319, 202-206.
    View publication on PubMed
Search for more literature for 1.14.11.65

Activating Compound

Activating Compound Comment Organism Structure
additional information local demethylation of H3K9me2 is triggered by recruitment of liganded estrogen receptor ERalpha to chromatin Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information LSD1 knockdown by siRNA inhibits 8-oxo-guanine production Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Pargyline
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleosome LSD1 is present on chromatin in both the presence and the absence of estrogens Homo sapiens 786
-
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 Homo sapiens
-
 [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
[histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-
fibroblast primary Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information LSD1 is also responsible for demethylation of H3K4me2 Homo sapiens ?
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2
-
 Homo sapiens [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
[histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
LSD1
-
 Homo sapiens
LSD1 demethylase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function H3 histone methylation and demethylation controls expression of estrogen-responsive genes, and DNA-bound estrogen receptor directs transcription by participating in bending chromatin to contact the RNA polymerase II recruited to the promoter driven by receptor-targeted demethylation of H3 lysine 9 through LSD1 at both enhancer and promoter sites, molecular mechanism, overview. The produced hydrogen peroxide, which modifies the surrounding DNA and recruits 8-oxoguanine–DNA glycosylase 1 and topoisomerase IIb, triggering chromatin and DNA conformational changes that are essential for estrogen-induced transcription Homo sapiens