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Literature summary for 1.14.11.65 extracted from

  • Cai, Y.; Fu, X.; Deng, Y.
    Histone demethylase JMJD1C regulates esophageal cancer proliferation Via YAP1 signaling (2017), Am. J. Cancer Res., 7, 115-124 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.65

Cloned(Commentary)

Cloned (Comment) Organism
quantitative RT-PCR enzyme expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information knockdown of JMJD1C in esophageal cancer cell lines, generation of Eca-109 and EC-18 EC cells that stably express JMJD1C shRNA Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 Homo sapiens
-
 histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q15652
-
-

Source Tissue

Source Tissue Comment Organism Textmining
EC-18 cell
-
 Homo sapiens
-
Eca109 cell
-
 Homo sapiens
-
esophageal epithelial cell
-
 Homo sapiens
-
esophageal epithelium enzyme JMJD1C is upregulated in patient esophageal cancer tissues and different esophageal cancer cell lines Homo sapiens
-
esophageal epithe­lial cell
-
 Homo sapiens
-
HKESC-1 cell
-
 Homo sapiens
-
KYSE-140 cell
-
 Homo sapiens
-
KYSE-30 cell
-
 Homo sapiens
-
NEEC-3 cell
-
 Homo sapiens
-
normal esophageal epithelial cell
-
 Homo sapiens
-
primary culture
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Homo sapiens histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
histone demethylase JMJD1C
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction knockdown of JMJD1C inhibits esophageal cancer cell proliferation. Knockdown of JMJD1C represses the protein and mRNA levels of YAP1 via regulating the H3K9me2 activity, but not the H3K9me1 activity. Inhibition of EC cell proliferation by the knockdown of JMJD1C is rescued by overexpression of YAP1, YAP1 acts as an oncogene in tumor progression Homo sapiens
physiological function histone demethylase JMJD1C regulates esophageal cancer proliferation via YAP1 signaling. JMJD1C controls the proliferation of esophageal cancer via modulation of H3K9me2 activity, targeting the YAP1 gene expression and functions as a tumor suppressor in esophageal cancer. JMJD1C levels are positively correlated with the TNM stage Homo sapiens