Cloned (Comment) | Organism |
---|---|
gene KDM7A, quantitative RT-PCR enzyme expression analysis | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | knockdown of KDM7A by siRNA transfection | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 | Homo sapiens | - |
histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q6ZMT4 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
microvascular endothelial cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 | - |
Homo sapiens | histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
KDM7A | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | knockdown of KDM7A by a small interfering RNA reduces the ICAM1 protein level and leukocyte adhesion without an effect on ICAM1 mRNA expression. In contrast, a KDM1B knockdown does not affect TNF-alpha-induced ICAM1 expression. Lysosome inhibitors increase the TNF-alpha-induced ICAM1 protein level and restore KDM7A knockdown-induced downregulation of ICAM1. In contrast, the KDM7A knockdown has no effect on proteasome-mediated ICAM1 degradation, but knockdown of KDM7A enhances CHX-induced ICAM1 protein degradation | Homo sapiens |
physiological function | histone demethylase KDM7A mediates TNF-alpha-induced ICAM1 protein upregulation by modulating lysosomal activity. KDM7A-mediated ICAM1 protein upregulation is likely related to protein stability, not a histone-mediated epigenetic mechanism, role of KDM7A in ICAM1 protein stabilization via a lysosome-dependent pathway, overview | Homo sapiens |