Cloned (Comment) | Organism |
---|---|
JMJD2A-C genes, DNA and amino acid sequence determination and analysis, expression of the GST-tagged isozymes JMJD2A, JMJD2B, and JMJD2C in Escherichia coli strain BL21(DE3) | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 | Homo sapiens | - |
[histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes JMJD2A, JMJD2B, and JMJD2C | - |
Purification (Comment) | Organism |
---|---|
recombinant GST-tagged isozymes JMJD2A, JMJD2B, and JMJD2C from Escherichia coli strain BL21(DE3) by glutathione affinity chromatography | Homo sapiens |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
specific isozyme activities with non-histone substrates, overview | Homo sapiens |
0.00029 | - |
recombinant purified isozyme JMJD2B, substrate histone H3K9 | Homo sapiens |
0.0005 | - |
recombinant purified isozyme JMJD2C, substrate histone H3K9 | Homo sapiens |
0.001 | - |
recombinant purified isozyme JMJD2A, substrate histone H3K9 | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | substrate specificity of recombinant isozymes, overview | Homo sapiens | ? | - |
? | |
[chromodomain Y-like protein]-N6,N6,N6-trimethyl-L-lysine135 + 2-oxoglutarate + O2 | - |
Homo sapiens | ? | - |
? | |
[Cockayne syndrome group B protein]-N6,N6,N6-trimethyl-L-lysine1054 + 2-oxoglutarate + O2 | - |
Homo sapiens | ? | - |
? | |
[Cockayne syndrome group B protein]-N6,N6,N6-trimethyl-L-lysine170 + 2-oxoglutarate + O2 | - |
Homo sapiens | ? | - |
? | |
[Cockayne syndrome group B protein]-N6,N6,N6-trimethyl-L-lysine297 + 2-oxoglutarate + O2 | - |
Homo sapiens | ? | - |
? | |
[Cockayne syndrome group B protein]-N6,N6,N6-trimethyl-L-lysine448 + 2-oxoglutarate + O2 | - |
Homo sapiens | ? | - |
? | |
[G9a protein]-N6,N6,N6-trimethyl-L-lysine185 + 2-oxoglutarate + O2 | a customer synthesized protein | Homo sapiens | ? | - |
? | |
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 | - |
Homo sapiens | [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 | isozyme JMJD2A substrate binding structure, overview | Homo sapiens | [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
[widely interspaced zinc finger motifs protein]-N6,N6,N6-trimethyl-L-lysine305 + 2-oxoglutarate + O2 | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
histone demethylase | - |
Homo sapiens |
JMJD2A | - |
Homo sapiens |
JMJD2B | - |
Homo sapiens |
JMJD2C | - |
Homo sapiens |
More | the enzyme belongs to the Jumonji domain-2 family histone demethylases | Homo sapiens |