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Literature summary for 1.14.11.66 extracted from

  • Shi, L.; Sun, L.; Li, Q.; Liang, J.; Yu, W.; Yi, X.; Yang, X.; Li, Y.; Han, X.; Zhang, Y.; Xuan, C.; Yao, Z.; Shang, Y.
    Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis (2011), Proc. Natl. Acad. Sci. USA, 108, 7541-7546.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
mouse Jmjd2b is transfected into JMJD2B-depleted MCF-7 cells, with stable transfection of JMJD2B-specific siRNA molecules Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information siRNA induced enzyme knockdown causes a decrease in the level of H3K9me3 at the promoters of ERalpha targets TFF1 and EBAG9 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 Homo sapiens
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 histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast carcinoma cell
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 Homo sapiens
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MCF-7 cell
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 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Homo sapiens histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
H3K9 trimethyl demethylase
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 Homo sapiens
histone demethylase
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 Homo sapiens
JMJD2B
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 Homo sapiens

General Information

General Information Comment Organism
malfunction depletion of JMJD2B impairs the estrogen-induced G1/S transition of the cell cycle in vitro and inhibits breast tumorigenesis in vivo. Cells with loss of function of JMJD2B display a substantial retention of H3K9me3 in the TFF1 and EBAG9 promoters upon estrogen receptor alpha activation, although the total histone H3 levels and H3K9me3 status on other gene promoters are not affected. H3K4 hypermethylation and H3K9 hypomethylation are prevalent histone marks that are associated with transcriptional activation Homo sapiens
additional information the H3K9 trimethyl demethylase JMJD2B is an integral component of the H3K4-specific methyltransferase, the mixed-lineage leukemia (MLL) 2 complex Homo sapiens
physiological function JMJD2B is able to demethylate H3K9me3 at pericentric heterochromatin in mammalian cells. Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis. JMJD2B promotes cell proliferation in vitro and tumorigenesis in vivo. The JMJD2B/MLL2 complex colocalizes with estrogen receptor alpha and is required for estrogen receptor alpha-regulated transcription. H3K9 demethylation and H3K4 methylation are coordinated in estrogen receptor alpha-activated transcription such that H3K9 demethylation is a prerequisite for H3K4 methylation. JMJD2B itself is an estrogen receptor alpha target gene, and forms a feed-forward regulatory loop in regulation of the hormone response, analysis of the in vivo interaction between JMJD2B and the MLL2 complex, overview Homo sapiens