Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | isoform KDM4D does not use [histone H3]-N6,N6,N6-trimethyl-L-lysine36 as substrate. All KDM4 proteins show no activity with [histone H3]-N6,N6-dimethyl-L-lysine36 | ? | - |
- |
|
[histone H3]-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2 | Mus musculus | - |
[histone H3]-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2 | - |
? | |
[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 | Mus musculus | preferred target for all KDM4 proteins, in general exhibiting 4fold preference for [histone H3]-N6,N6,N6-trimethyl-L-lysine9 over [histone H3]-N6,N6,N6-trimethyl-L-lysine36. The preference for [histone H3]-N6,N6,N6-trimethyl-L-lysine9 over [histone H3]-N6,N6-dimethyl-L-lysine9 is more modest form KDM4A (less than 3fold), KDM4B (less than 1.5fold), and KDM4D (less than 2.5fold), while the preference for KDM4C is nearly equivalent | [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 | Mus musculus | - |
[histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | isoform KDM4D does not use [histone H3]-N6,N6,N6-trimethyl-L-lysine36 as substrate. All KDM4 proteins show no activity with [histone H3]-N6,N6-dimethyl-L-lysine36 | Mus musculus | ? | - |
- |
|
[histone H3]-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2 | - |
Mus musculus | [histone H3]-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2 | - |
? | |
[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 | preferred target for all KDM4 proteins, in general exhibiting 4fold preference for [histone H3]-N6,N6,N6-trimethyl-L-lysine9 over [histone H3]-N6,N6,N6-trimethyl-L-lysine36. The preference for [histone H3]-N6,N6,N6-trimethyl-L-lysine9 over [histone H3]-N6,N6-dimethyl-L-lysine9 is more modest form KDM4A (less than 3fold), KDM4B (less than 1.5fold), and KDM4D (less than 2.5fold), while the preference for KDM4C is nearly equivalent | Mus musculus | [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 | - |
Mus musculus | [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
JMJD2 | Jumonji D2, gene name | Mus musculus |
KDM4 | - |
Mus musculus |
KDM4A | isoform | Mus musculus |
KDM4B | isoform | Mus musculus |
Kdm4c | isoform | Mus musculus |
KDM4D | isoform | Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | the enzyme is overexpressed in many cancer types | up |
General Information | Comment | Organism |
---|---|---|
physiological function | enzyme overexpression contributes to the maintenance of a pluripotent state and induces numerous oncogenic effects. KDM4 proteins are a component of the cellular response to postreplicative and exogenous DNA damage | Mus musculus |