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Literature summary for 1.14.11.66 extracted from

  • Young, L.C.; Hendzel, M.J.
    The oncogenic potential of Jumonji D2 (JMJD2/KDM4) histone demethylase overexpression (2013), Biochem. Cell Biol., 91, 369-377 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus isoform KDM4D does not use [histone H3]-N6,N6,N6-trimethyl-L-lysine36 as substrate. All KDM4 proteins show no activity with [histone H3]-N6,N6-dimethyl-L-lysine36 ?
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[histone H3]-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2 Mus musculus
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[histone H3]-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 Mus musculus preferred target for all KDM4 proteins, in general exhibiting 4fold preference for [histone H3]-N6,N6,N6-trimethyl-L-lysine9 over [histone H3]-N6,N6,N6-trimethyl-L-lysine36. The preference for [histone H3]-N6,N6,N6-trimethyl-L-lysine9 over [histone H3]-N6,N6-dimethyl-L-lysine9 is more modest form KDM4A (less than 3fold), KDM4B (less than 1.5fold), and KDM4D (less than 2.5fold), while the preference for KDM4C is nearly equivalent [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 Mus musculus
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[histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information isoform KDM4D does not use [histone H3]-N6,N6,N6-trimethyl-L-lysine36 as substrate. All KDM4 proteins show no activity with [histone H3]-N6,N6-dimethyl-L-lysine36 Mus musculus ?
-
-
[histone H3]-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
-
Mus musculus [histone H3]-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 preferred target for all KDM4 proteins, in general exhibiting 4fold preference for [histone H3]-N6,N6,N6-trimethyl-L-lysine9 over [histone H3]-N6,N6,N6-trimethyl-L-lysine36. The preference for [histone H3]-N6,N6,N6-trimethyl-L-lysine9 over [histone H3]-N6,N6-dimethyl-L-lysine9 is more modest form KDM4A (less than 3fold), KDM4B (less than 1.5fold), and KDM4D (less than 2.5fold), while the preference for KDM4C is nearly equivalent Mus musculus [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
Mus musculus [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
?

Synonyms

Synonyms Comment Organism
JMJD2 Jumonji D2, gene name Mus musculus
KDM4
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Mus musculus
KDM4A isoform Mus musculus
KDM4B isoform Mus musculus
Kdm4c isoform Mus musculus
KDM4D isoform Mus musculus

Expression

Organism Comment Expression
Mus musculus the enzyme is overexpressed in many cancer types up

General Information

General Information Comment Organism
physiological function enzyme overexpression contributes to the maintenance of a pluripotent state and induces numerous oncogenic effects. KDM4 proteins are a component of the cellular response to postreplicative and exogenous DNA damage Mus musculus