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Literature summary for 1.14.11.67 extracted from

  • Klose, R.J.; Yan, Q.; Tothova, Z.; Yamane, K.; Erdjument-Bromage, H.; Tempst, P.; Gilliland, D.G.; Zhang, Y.; Kaelin, W.G.
    The retinoblastoma binding protein RBP2 is an H3K4 demethylase (2007), Cell, 128, 889-900.
    View publication on PubMed
Search for more literature for 1.14.11.67

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[histone-H3]-dimethyllysine4 + 2-oxoglutarate + O2 Mus musculus RBP2 is a demethylase that specifically catalyzes demethylation. The enzyme is capable of erasing trimethylated H3K4. The enzyme is capable of processively demethylating the H3K4me3 and me2 modifications to the unmodified state ?
-
 ?
[histone-H3]-tridimethyllysine4 + 2-oxoglutarate + O2 Mus musculus RBP2 is a demethylase that specifically catalyzes demethylation. RBP2 displayes robust H3K4 demethylase activity against H3K4me3 and me2, resulting in 80%-90% demethylation of the modified substrate, but fails to catalyze removal of the me1 modification state. The enzyme is capable of processively demethylating the H3K4me3 and me2 modifications to the unmodified state ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast embryonic Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[histone-H3]-dimethyllysine4 + 2-oxoglutarate + O2 RBP2 is a demethylase that specifically catalyzes demethylation. RBP2 displayes robust H3K4 demethylase activity against H3K4me3 and me2, resulting in 80%-90% demethylation of the modified substrate, but fails to catalyze removal of the me1 modification state. The enzyme is capable of processively demethylating the H3K4me3 and me2 modifications to the unmodified state Mus musculus ?
-
 ?
[histone-H3]-dimethyllysine4 + 2-oxoglutarate + O2 RBP2 is a demethylase that specifically catalyzes demethylation. The enzyme is capable of erasing trimethylated H3K4. The enzyme is capable of processively demethylating the H3K4me3 and me2 modifications to the unmodified state Mus musculus ?
-
 ?
[histone-H3]-tridimethyllysine4 + 2-oxoglutarate + O2 RBP2 is a demethylase that specifically catalyzes demethylation. RBP2 displayes robust H3K4 demethylase activity against H3K4me3 and me2, resulting in 80%-90% demethylation of the modified substrate, but fails to catalyze removal of the me1 modification state. The enzyme is capable of processively demethylating the H3K4me3 and me2 modifications to the unmodified state Mus musculus ?
-
 ?
[histone-H3]-trimethyllysine4 + 2-oxoglutarate + O2 RBP2 is a demethylase that specifically catalyzes demethylation. RBP2 displayes robust H3K4 demethylase activity against H3K4me3 and me2, resulting in 80%-90% demethylation of the modified substrate, but fails to catalyze removal of the me1 modification state. The enzyme is capable of processively demethylating the H3K4me3 and me2 modifications to the unmodified state Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
H3K4 demethylase
-
 Mus musculus
RBP2
-
 Mus musculus
retinoblastoma binding protein 2
-
 Mus musculus