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Literature summary for 1.14.11.67 extracted from

  • Lloret-Llinares, M.; Carre, C.; Vaquero, A.; de Olano, N.; Azorin, F.
    Characterization of Drosophila melanogaster JmjC+N histone demethylases (2008), Nucleic Acids Res., 36, 2852-2863.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of FLAG-tagged CG15835 in S2 cells Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Drosophila melanogaster 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ activates, required Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Drosophila melanogaster isoform dJMJD2(1)/CG15835 regulates heterochromatin organization. It is excluded from heterochromatin and localizes to multiple euchromatic sites, where it regulates trimethylated histone 3 lysine 36 methylation ?
-
?
[histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 Drosophila melanogaster
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[histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2
-
?
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 Drosophila melanogaster
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[histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-
Drosophila melanogaster Q9V333 isoform dJMJD2(1)/CG15835
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Drosophila melanogaster Q9V6L0 isoform dJMJD2(2)/CG33182
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information isoform dJMJD2(1)/CG15835 regulates heterochromatin organization. It is excluded from heterochromatin and localizes to multiple euchromatic sites, where it regulates trimethylated histone 3 lysine 36 methylation Drosophila melanogaster ?
-
?
additional information demethylase activity of dJMJD2(1)/CG15835 depends on the JmjC domain. No activity with H3K4me3 and H3K27me3 by dJMJD2(1)/CG15835 and dJMJD2(2)/CG33182 Drosophila melanogaster ?
-
?
trimethyl-histone 3 L-lysine 36 + alpha-ketoglutarate + O2
-
Drosophila melanogaster dimethyl-histone 3 L-lysine 36 + ?
-
?
[histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2
-
Drosophila melanogaster [histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2
-
?
[histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 dJMJD2(1)/CG15835 and dJMJD2(2)/CG33182 demethylate both H3K9me3 and H3K36me3 Drosophila melanogaster [histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2
-
?
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2
-
Drosophila melanogaster [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
?
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 dJMJD2(1)/CG15835 and dJMJD2(2)/CG33182 demethylate both H3K9me3 and H3K36me3 Drosophila melanogaster [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
?

Subunits

Subunits Comment Organism
More domain organization and sequence homology analysis of JmjC+N proteins, overview Drosophila melanogaster

Synonyms

Synonyms Comment Organism
CG33182
-
Drosophila melanogaster
CG33185
-
Drosophila melanogaster
dJMJD2(1)
-
Drosophila melanogaster
dJMJD2(1)/CG15835
-
Drosophila melanogaster
dJMJD2(2)
-
Drosophila melanogaster
dJMJD2(2)/CG33182
-
Drosophila melanogaster
JmjC domain-containing histone demethylation protein 3A
-
Drosophila melanogaster
JmjC domain-containing histone demethylation protein 3b
-
Drosophila melanogaster
JmjC+N
-
Drosophila melanogaster
JmjC+N histone demethylase
-
Drosophila melanogaster
More the isozymes belongs to the JmjC+N protein family, CG33182 and CG33185 are JMJD2 proteins Drosophila melanogaster

Expression

Organism Comment Expression
Drosophila melanogaster CG15835 overexpression induces spreading of HP1, out of heterochromatin, into euchromatin, without affecting the actual pattern of histone modifications of heterochromatin. Overexpression of dJMJD2(1)/CG15835 results in a strong decrease on the levels of H3K9me3 and H3K36me3, but it does not show any significant effect on the extent of H3K9me3 and H3K9me2 at the chromocentre up

General Information

General Information Comment Organism
physiological function dJMJD2(1)/CG15835 is excluded from heterochromatin and localizes to multiple euchromatic sites, where it regulates H3K36 methylation and heterochromatin organization. CG15835 contributes to delimit hetero- and euchromatic territories through the regulation of H3K36 methylation in euchromatin Drosophila melanogaster