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Literature summary for 1.14.11.67 extracted from

  • Kavi, H.H.; Birchler, J.A.
    Drosophila KDM2 is a H3K4me3 demethylase regulating nucleolar organization (2009), BMC Res. Notes, 2, 217.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information transgenic flies expressing inverted repeats of the CG11033 coding region under the influence of the UAS promoter are crossed with act5CGal4 flies. The presence of Gal4 leads to transcription of inverted repeats under the influence of UAS promoter bearing Gal4 binding sites. Flies bearing only the inverted repeats are used as a control. The expression of dsRNA arising out of transcription of inverted repeats brings about downregulation of CG11033. The mutants exhibit multiple nucleoli, which are smaller in size. Quantitative real time PCR analysis shows reduction of dKDM2 transcript level relative to tubulin mRNA level in RNAi knockdown larvae. Analysis of histone modifications in the dKDM2 RNAi knockdown mutants, overview Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 3 2-oxoglutarate + 3 O2 Drosophila melanogaster dKDM2 is a histone lysine demethylase with specificity for H3K4me3, not H3K36me2, and regulates nucleolar organization. H3K4me3 modification is the site of active transcription [histone H3]-L-lysine4 + 3 succinate + 3 formaldehyde + 3 CO2
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Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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 gene CG11033
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 3 2-oxoglutarate + 3 O2
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 Drosophila melanogaster [histone H3]-L-lysine4 + 3 succinate + 3 formaldehyde + 3 CO2
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 ?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 3 2-oxoglutarate + 3 O2 dKDM2 is a histone lysine demethylase with specificity for H3K4me3, not H3K36me2, and regulates nucleolar organization. H3K4me3 modification is the site of active transcription Drosophila melanogaster [histone H3]-L-lysine4 + 3 succinate + 3 formaldehyde + 3 CO2
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 ?

Synonyms

Synonyms Comment Organism
H3K4me3 demethylase
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 Drosophila melanogaster
KDM2
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 Drosophila melanogaster
Lid
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 Drosophila melanogaster

General Information

General Information Comment Organism
malfunction H3K4me3 is an important epigenetic landmark for active transcription, failure to erase this mark can result in aberrant transcription of rDNA repeats and failure to form a single compact nucleolus Drosophila melanogaster
physiological function dKDM2 plays an important role in nucleolar structure organization Drosophila melanogaster