Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.11.67 extracted from

  • Pasini, D.; Hansen, K.; Christensen, J.; Agger, K.; Cloos, P.; Helin, K.
    Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2 (2008), Genes Dev., 22, 1345-1355.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the PRC2 enzyme complex recruits H3K4me3 demethylase Rbp2 to its target genes, where its acts as mediator for the repressive activity of the PRC2 complex during embryonic stem cell differentiation, Rbp2 binds directly to the PRC2 complex, overview ?
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 3 2-oxoglutarate + 3 O2 Mus musculus
-
[histone H3]-L-lysine4 + 3 succinate + 3 formaldehyde + 3 CO2
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic stem cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the PRC2 enzyme complex recruits H3K4me3 demethylase Rbp2 to its target genes, where its acts as mediator for the repressive activity of the PRC2 complex during embryonic stem cell differentiation, Rbp2 binds directly to the PRC2 complex, overview Mus musculus ?
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 3 2-oxoglutarate + 3 O2
-
Mus musculus [histone H3]-L-lysine4 + 3 succinate + 3 formaldehyde + 3 CO2
-
?

Synonyms

Synonyms Comment Organism
H3K4 demethylase
-
Mus musculus
Jarid1a
-
Mus musculus
RBP2
-
Mus musculus

General Information

General Information Comment Organism
physiological function the enzyme is involved in the mechanism for repression of developmental genes by the coordinated regulation of epigenetic marks involved in repression and activation of transcription Mus musculus