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Literature summary for 1.14.11.67 extracted from

  • Dey, B.; Stalker, L.; Schnerch, A.; Bhatia, M.; Taylor-Papidimitriou, J.; Wynder, C.
    The histone demethylase KDM5b/JARID1b plays a role in cell fate decisions by blocking terminal differentiation (2008), Mol. Cell. Biol., 28, 5312-5327.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
overexpression of KDM5b in embryonic stem cells as Flag-tagged and EGFP-tagged protein. Constitutive expression of KDM5b modifies embryonic stem cell proliferation and 3meH3K4 levels. Quantitative RT-PCR expression analysis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information transient overexpression of KDM5b in embryonic stem cells decreases the expression of at least three different modulators of cell fate decisions, Egr1, p27KIP1, and BMI1, by demethylation of their promoters. Constitutively increased KDM5b expression results in an increased mitotic rate and a decreased global 3meH3K4 but no change in cell identity Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2 Mus musculus KDM5b specifically demethylates lysine 4 of histone H3, thereby repressing gene transcription [histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
embryonic stem cell
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 Mus musculus
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epiblast expression in the early epiblast Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2
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 Mus musculus [histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
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 ?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2 KDM5b specifically demethylates lysine 4 of histone H3, thereby repressing gene transcription Mus musculus [histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
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 ?

Synonyms

Synonyms Comment Organism
histone demethylase
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 Mus musculus
KDM5b/JARID1b
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 Mus musculus
lysine demethylase 5b
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 Mus musculus

General Information

General Information Comment Organism
physiological function KDM5b regulates cell cycle control genes in cancer. It KDM5b reduces the terminally differentiated cells and increases proliferating progenitors in cell differentiation, mechanisms, overview. Role for KDM5b in the choice between proliferation and differentiation during development Mus musculus