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Literature summary for 1.14.11.69 extracted from

  • Lin, C.H.; Li, B.; Swanson, S.; Zhang, Y.; Florens, L.; Washburn, M.P.; Abmayr, S.M.; Workman, J.L.
    Heterochromatin protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase (2008), Mol. Cell, 32, 696-706 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.69

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyllysine36 + 2 2-oxoglutarate + 2 O2 Drosophila melanogaster
-
 [histone H3]-N6-methyllysine36 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
[histone H3]-N6,N6,N6-trimethyllysine36 + 2-oxoglutarate + O2 Drosophila melanogaster
-
 [histone H3]-N6,N6-dimethyllysine36 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6-dimethyllysine36 + 2-oxoglutarate + O2 Drosophila melanogaster
-
 [histone H3]-N6-methyllysine36 + succinate + formaldehyde + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster Q9V333
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyllysine36 + 2 2-oxoglutarate + 2 O2
-
 Drosophila melanogaster [histone H3]-N6-methyllysine36 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
[histone H3]-N6,N6,N6-trimethyllysine36 + 2-oxoglutarate + O2
-
 Drosophila melanogaster [histone H3]-N6,N6-dimethyllysine36 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6-dimethyllysine36 + 2-oxoglutarate + O2
-
 Drosophila melanogaster [histone H3]-N6-methyllysine36 + succinate + formaldehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
KDM4A,
-
 Drosophila melanogaster

General Information

General Information Comment Organism
physiological function KDM4A specifically demethylates H3K36me2 and me3 both in vitro and in vivo. Heterochromatin Protein 1a (HP1a) associates with KDMA4A. The chromoshadow domain of HP1a and a HP1-interacting motif of KDM4A are responsible for this interaction. HP1a stimulates the histone H3K36 demethylation activity of dKDM4A. Loss of HP1a leads to increased level of histone H3K36me3 Drosophila melanogaster