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Literature summary for 1.14.11.78 extracted from

  • Jonnalagadda, R.; Del Rio Flores, A.; Cai, W.; Mehmood, R.; Narayanamoorthy, M.; Ren, C.; Zaragoza, J.; Kulik, H.; Zhang, W.; Drennan, C.
    Biochemical and crystallographic investigations into isonitrile formation by a nonheme iron-dependent oxidase/ decarboxylase (2021), J. Biol. Chem., 296, 100231 .
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Streptomyces coeruleorubidus

Crystallization (Commentary)

Crystallization (Comment) Organism
structures of Fe(II)-bound ScoE, to 1.45-1.96 A resolution. ScoE has an inducible 2-oxtoglutarate binding site, in which residues arginine-157 and histidine-299 move by approximately 10 A from the surface of the protein into the active site to create a transient 2-oxoglutarate binding pocket. Oxovanadium mimicks Fe(II) Streptomyces coeruleorubidus

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+
-
 Streptomyces coeruleorubidus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a (3R)-3-[(carboxylmethyl)amino]fatty acid + 2 2-oxoglutarate + 2 O2 Streptomyces coeruleorubidus
-
 a (3R)-3-isocyanyl-fatty acid + 2 succinate + 3 CO2 + 2 H2O
-
 ?
a (3R)-3-[(carboxylmethyl)amino]fatty acid + 2-oxoglutarate + O2 Streptomyces coeruleorubidus
-
 a (3R)-3-[carboxy(hydroxy)methyl]amino fatty acid + succinate + CO2
-
 ?
a (3R)-3-[carboxy(hydroxy)methyl]amino fatty acid + 2-oxoglutarate + O2 Streptomyces coeruleorubidus
-
 a (3R)-3-isocyanyl-fatty acid + succinate + 2 CO2 + 2 H2O
-
 ?
additional information Streptomyces coeruleorubidus an 1:1:1 correlation exists between 2-oxoglutarate consumption, oxygen consumption, and succinate formation. The reaction does not produce H2O2 ?
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-

Organism

Organism UniProt Comment Textmining
Streptomyces coeruleorubidus A0A3B6UEU3
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a (3R)-3-[(carboxylmethyl)amino]fatty acid + 2 2-oxoglutarate + 2 O2
-
 Streptomyces coeruleorubidus a (3R)-3-isocyanyl-fatty acid + 2 succinate + 3 CO2 + 2 H2O
-
 ?
a (3R)-3-[(carboxylmethyl)amino]fatty acid + 2-oxoglutarate + O2
-
 Streptomyces coeruleorubidus a (3R)-3-[carboxy(hydroxy)methyl]amino fatty acid + succinate + CO2
-
 ?
a (3R)-3-[carboxy(hydroxy)methyl]amino fatty acid + 2-oxoglutarate + O2
-
 Streptomyces coeruleorubidus a (3R)-3-isocyanyl-fatty acid + succinate + 2 CO2 + 2 H2O
-
 ?
additional information an 1:1:1 correlation exists between 2-oxoglutarate consumption, oxygen consumption, and succinate formation. The reaction does not produce H2O2 Streptomyces coeruleorubidus ?
-
-