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Literature summary for 1.14.11.79 extracted from

  • Bundred, J.; Hendrix, E.; Coleman, M.
    The emerging roles of ribosomal histidyl hydroxylases in cell biology, physiology and disease (2018), Cell. Mol. Life Sci., 75, 4093-4105 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.79

Application

Application Comment Organism
medicine MINA53 is overexpressed in multiple cancer types, blocking MINA53 expression limits the proliferative capacity of several tumor cell lines in vitro. MINA53 acts as an immuno-modulator Homo sapiens
medicine NO66 inhibits the ability of Osterix to drive osteoblast-specific gene transcription. Overexpression of NO66 is sufficient to suppress the transactivation domain of Osterix. Mesenchymal-specific ablation of NO66 increases the expression of genes that promote bone growth and development in mice Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleolus
-
 Homo sapiens 5730
-
ribosome
-
 Homo sapiens 5840
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens NHXH is the preferred motif for hydroxylation ?
-
-
[Rpl27a]-L-histidine39 + 2-oxoglutarate + O2 Homo sapiens substrate i.e. large ribosomal subunit protein [Rpl27a]-(3S)-3-hydroxy-L-histidine39 + succinate + CO2
-
 ?
[Rpl8]-L-histidine216 + 2-oxoglutarate + O2 Homo sapiens substrate i.e. 60S ribosomal protein [Rpl8]-(3S)-3-hydroxy-L-histidine216 + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8IUF8 isoform Riox2
-
Homo sapiens Q9H6W3 isoform Riox1, cf. EC 1.14.11.27
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information NHXH is the preferred motif for hydroxylation Homo sapiens ?
-
-
[Rpl27a]-L-histidine39 + 2-oxoglutarate + O2 substrate i.e. large ribosomal subunit protein Homo sapiens [Rpl27a]-(3S)-3-hydroxy-L-histidine39 + succinate + CO2
-
 ?
[Rpl8]-L-histidine216 + 2-oxoglutarate + O2 substrate i.e. 60S ribosomal protein Homo sapiens [Rpl8]-(3S)-3-hydroxy-L-histidine216 + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
MINA53
-
 Homo sapiens
NO66
-
 Homo sapiens
RIOX2
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens expression is regulated by growth-responsive transcription factors additional information

General Information

General Information Comment Organism
evolution MINA53 belongs to a group of JmjC 2OG-oxygenases that does not contain other obvious functional domains Homo sapiens
evolution NO66 belongs to a group of JmjC 2OG-oxygenases that does not contain other obvious functional domains Homo sapiens
physiological function NO66 hydroxylation reaction serves to properly orientate the 28S rRNA in the vicinity of the peptidyl transferase center Homo sapiens