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Literature summary for 1.14.11.8 extracted from

  • Al Temimi, A.H.; Pieters, B.J.; Reddy, Y.V.; White, P.B.; Mecinovic, J.
    Substrate scope for trimethyllysine hydroxylase catalysis (2016), Chem. Commun. (Camb.), 52, 12849-12852 .
    View publication on PubMed
Search for more literature for 1.14.11.8

Activating Compound

Activating Compound Comment Organism Structure
ascorbate required Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ dependent on, non-heme Fe(II) and 2-oxoglutarate dependent oxygenase, Fe2+ is required for catalysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 Homo sapiens
-
 (3S)-3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NVH6
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information NMR spectrosopic structure analysis of substrates and products, substrate specificity, overview. No or poor activity with dimethyllysine, methyllysine, lysine, D-trimethyllysine, 5-trimethylamino-1-aminopentane, trimethyllysine, 6-trimethylaminohexanoic acid, hexamethyllysine, N-acetyltrimethyllysine, trimethyldiaminobutyric acid, triethyllysine, symmetric and asymmetric dimethylarginines, mildronate, and gamma-butyrobetaine, structure-activity relationship study Homo sapiens ?
-
 ?
N5,N5,N5-trimethyl-L-ornithine + 2-oxoglutarate + O2
-
 Homo sapiens (3S)-3-hydroxy-N5,N5,N5-trimethyl-L-ornithine + succinate + CO2
-
 ?
N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2
-
 Homo sapiens (3S)-3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2
-
 ?
N6,N6-dimethyl-N6-ethyl-L-lysine + 2-oxoglutarate + O2
-
 Homo sapiens (3S)-3-hydroxy-N6,N6-dimethyl-N6-ethyl-L-lysine + succinate + CO2
-
 ?
N6,N6-dimethyl-N6-isopropyl-L-lysine + 2-oxoglutarate + O2
-
 Homo sapiens (3S)-3-hydroxy-N6,N6-dimethyl-N6-isopropyl-L-lysine + succinate + CO2
-
 ?
N6,N6-dimethyl-N6-propyl-L-lysine + 2-oxoglutarate + O2
-
 Homo sapiens (3S)-3-hydroxy-N6,N6-dimethyl-N6-propyl-L-lysine + succinate + CO2
-
 ?
N7,N7,N7-trimethyl-L-alpha-homolysine + 2-oxoglutarate + O2
-
 Homo sapiens (3S)-3-hydroxy-N7,N7,N7-trimethyl-L-alpha-homolysine + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
TMLH
-
 Homo sapiens
trimethyllysine hydroxylase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Homo sapiens

General Information

General Information Comment Organism
evolution the enzyme belongs to the non-heme Fe(II) and 2-oxoglutarate dependent oxygenases Homo sapiens
metabolism trimethyllysine hydroxylase (TMLH) catalyses C-3 hydroxylation of Nepsilon-trimethyllysine in the first step of carnitine biosynthesis Homo sapiens
additional information residue Asp131 in TMLHis responsible for specific binding of the alpha-ammonium group of trimethyllysine Homo sapiens
physiological function trimethyllysine hydroxylase (TMLH) catalyses C-3 hydroxylation of Nepsilon-trimethyllysine in the first step of carnitine biosynthesis Homo sapiens