Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | trimethylation of H3K56 is removed by members of the JMJD2 family of demethylases that also target H3K9me3, reaction of EC 1.14.11.65 | ? | - |
? | |
additional information | Mus musculus | trimethylation of H3K56 is removed by members of the JMJD2 family of demethylases that also target H3K9me3, reaction of EC 1.14.11.65 | ? | - |
? | |
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2 2-oxoglutarate + 2 O2 | Homo sapiens | - |
[histone H3]-N6-methyl-L-lysine56 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2 2-oxoglutarate + 2 O2 | Mus musculus | - |
[histone H3]-N6-methyl-L-lysine56 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2-oxoglutarate + O2 | Homo sapiens | - |
[histone H3]-N6,N6-dimethyl-L-lysine56 + succinate + formaldehyde + CO2 | - |
? | |
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2-oxoglutarate + O2 | Mus musculus | - |
[histone H3]-N6,N6-dimethyl-L-lysine56 + succinate + formaldehyde + CO2 | - |
? | |
[histone H3]-N6,N6-dimethyl-L-lysine56 + 2-oxoglutarate + O2 | Homo sapiens | - |
[histone H3]-N6-methyl-L-lysine56 + succinate + formaldehyde + CO2 | - |
? | |
[histone H3]-N6,N6-dimethyl-L-lysine56 + 2-oxoglutarate + O2 | Mus musculus | - |
[histone H3]-N6-methyl-L-lysine56 + succinate + formaldehyde + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | B2RXH2 | cf. EC 1.14.11.65 | - |
Mus musculus | Q3U2K5 | isoform JMJD2d | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | low expression level | Homo sapiens | - |
C-127 cell | - |
Mus musculus | - |
fibroblast | embryonic fibroblast cell | Mus musculus | - |
HL-60 cell | low expression level | Homo sapiens | - |
testis | predominant expression | Homo sapiens | - |
U2-OS cell | low expression level | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | trimethylation of H3K56 is removed by members of the JMJD2 family of demethylases that also target H3K9me3, reaction of EC 1.14.11.65 | Homo sapiens | ? | - |
? | |
additional information | trimethylation of H3K56 is removed by members of the JMJD2 family of demethylases that also target H3K9me3, reaction of EC 1.14.11.65 | Mus musculus | ? | - |
? | |
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2 2-oxoglutarate + 2 O2 | - |
Homo sapiens | [histone H3]-N6-methyl-L-lysine56 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2 2-oxoglutarate + 2 O2 | - |
Mus musculus | [histone H3]-N6-methyl-L-lysine56 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2-oxoglutarate + O2 | - |
Homo sapiens | [histone H3]-N6,N6-dimethyl-L-lysine56 + succinate + formaldehyde + CO2 | - |
? | |
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2-oxoglutarate + O2 | - |
Mus musculus | [histone H3]-N6,N6-dimethyl-L-lysine56 + succinate + formaldehyde + CO2 | - |
? | |
[histone H3]-N6,N6-dimethyl-L-lysine56 + 2-oxoglutarate + O2 | - |
Homo sapiens | [histone H3]-N6-methyl-L-lysine56 + succinate + formaldehyde + CO2 | - |
? | |
[histone H3]-N6,N6-dimethyl-L-lysine56 + 2-oxoglutarate + O2 | - |
Mus musculus | [histone H3]-N6-methyl-L-lysine56 + succinate + formaldehyde + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
JMJD2D | - |
Mus musculus |
KDM4DL | - |
Homo sapiens |
KDM4E | - |
Homo sapiens |
lysine-specific demethylase 4E | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | overexpression of human KDM4E strongly diminishes [histone H3]-N6,N6,N6-trimethyl-L-lysine9, as well as [histone H3]-N6,N6,N6-trimethyl-L-lysine56 signals, in HeLa Kyoto cells. The loss of the respective trimethyl signal is accompanied with an increase in the monomethyl, but not dimethyl state. the activity is dependent on the enzymatic active jmjC domain | Homo sapiens |
physiological function | overexpression of mouse Jmjd2D strongly diminishes [histone H3]-N6,N6,N6-trimethyl-L-lysine9, as well as [histone H3]-N6,N6,N6-trimethyl-L-lysine56 signals, in HeLa Kyoto cells. The loss of the respective trimethyl signal is accompanied with an increase in the monomethyl, but not dimethyl state. the activity is dependent on the enzymatic active jmjC domain | Mus musculus |