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Literature summary for 1.14.11.B19 extracted from

  • Jack, A.P.M.; Bussemer, S.; Hahn, M.; Pünzeler, S.; Snyder, M.; Wells, M.; Csankovszki, G.; Solovei, I.; Schotta, G.; Hake, S.B.
    H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization (2013), PLoS ONE, 8, e51765 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens trimethylation of H3K56 is removed by members of the JMJD2 family of demethylases that also target H3K9me3, reaction of EC 1.14.11.65 ?
-
?
additional information Mus musculus trimethylation of H3K56 is removed by members of the JMJD2 family of demethylases that also target H3K9me3, reaction of EC 1.14.11.65 ?
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2 2-oxoglutarate + 2 O2 Homo sapiens
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[histone H3]-N6-methyl-L-lysine56 + 2 succinate + 2 formaldehyde + 2 CO2
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2 2-oxoglutarate + 2 O2 Mus musculus
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[histone H3]-N6-methyl-L-lysine56 + 2 succinate + 2 formaldehyde + 2 CO2
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2-oxoglutarate + O2 Homo sapiens
-
[histone H3]-N6,N6-dimethyl-L-lysine56 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2-oxoglutarate + O2 Mus musculus
-
[histone H3]-N6,N6-dimethyl-L-lysine56 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6,N6-dimethyl-L-lysine56 + 2-oxoglutarate + O2 Homo sapiens
-
[histone H3]-N6-methyl-L-lysine56 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6,N6-dimethyl-L-lysine56 + 2-oxoglutarate + O2 Mus musculus
-
[histone H3]-N6-methyl-L-lysine56 + succinate + formaldehyde + CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens B2RXH2 cf. EC 1.14.11.65
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Mus musculus Q3U2K5 isoform JMJD2d
-

Source Tissue

Source Tissue Comment Organism Textmining
brain low expression level Homo sapiens
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C-127 cell
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Mus musculus
-
fibroblast embryonic fibroblast cell Mus musculus
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HL-60 cell low expression level Homo sapiens
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testis predominant expression Homo sapiens
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U2-OS cell low expression level Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information trimethylation of H3K56 is removed by members of the JMJD2 family of demethylases that also target H3K9me3, reaction of EC 1.14.11.65 Homo sapiens ?
-
?
additional information trimethylation of H3K56 is removed by members of the JMJD2 family of demethylases that also target H3K9me3, reaction of EC 1.14.11.65 Mus musculus ?
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2 2-oxoglutarate + 2 O2
-
Homo sapiens [histone H3]-N6-methyl-L-lysine56 + 2 succinate + 2 formaldehyde + 2 CO2
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2 2-oxoglutarate + 2 O2
-
Mus musculus [histone H3]-N6-methyl-L-lysine56 + 2 succinate + 2 formaldehyde + 2 CO2
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2-oxoglutarate + O2
-
Homo sapiens [histone H3]-N6,N6-dimethyl-L-lysine56 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2-oxoglutarate + O2
-
Mus musculus [histone H3]-N6,N6-dimethyl-L-lysine56 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6,N6-dimethyl-L-lysine56 + 2-oxoglutarate + O2
-
Homo sapiens [histone H3]-N6-methyl-L-lysine56 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6,N6-dimethyl-L-lysine56 + 2-oxoglutarate + O2
-
Mus musculus [histone H3]-N6-methyl-L-lysine56 + succinate + formaldehyde + CO2
-
?

Synonyms

Synonyms Comment Organism
JMJD2D
-
Mus musculus
KDM4DL
-
Homo sapiens
KDM4E
-
Homo sapiens
lysine-specific demethylase 4E
-
Homo sapiens

General Information

General Information Comment Organism
physiological function overexpression of human KDM4E strongly diminishes [histone H3]-N6,N6,N6-trimethyl-L-lysine9, as well as [histone H3]-N6,N6,N6-trimethyl-L-lysine56 signals, in HeLa Kyoto cells. The loss of the respective trimethyl signal is accompanied with an increase in the monomethyl, but not dimethyl state. the activity is dependent on the enzymatic active jmjC domain Homo sapiens
physiological function overexpression of mouse Jmjd2D strongly diminishes [histone H3]-N6,N6,N6-trimethyl-L-lysine9, as well as [histone H3]-N6,N6,N6-trimethyl-L-lysine56 signals, in HeLa Kyoto cells. The loss of the respective trimethyl signal is accompanied with an increase in the monomethyl, but not dimethyl state. the activity is dependent on the enzymatic active jmjC domain Mus musculus