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Literature summary for 1.14.12.12 extracted from

  • Chopard, C.; Azerad, R.; Prange, T.
    Naphthalene-dioxygenase-catalyzed cis-dihydroxylation of azaarene derivatives. Part 1: 2-Pyridones and 2-quinolones (2008), J. Mol. Catal. B, 50, 53-60.
No PubMed abstract available

Organism

Organism UniProt Comment Textmining
Pseudomonas sp.
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NCIB 9816-4. Enzyme is recombinantly expressed in Escherichia coli
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information biotransformation of 2-pyridone- and 2-quinolone-derived compounds by recombinant whole-cells of Escherichia coli JM109(DE3)(pDTG141) expressing the naphthalene-dioxygenase system from Pseudomonas sp. NCIB 9816-4, using a series of N- and C-substituted derivatives. Among them, only the N-methyl substituted compounds are good substrates for a regio- and stereoselective dihydroxylation reaction leading to cis-dihydroxydihydro pyridone derivatives Pseudomonas sp. ?
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