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Literature summary for 1.14.12.17 extracted from

  • Hallstrom, C.K.; Gardner, A.M.; Gardner, P.R.
    Nitric oxide metabolism in mammalian cells: substrate and inhibitor profiles of a NADPH-cytochrome P450 oxidoreductase-coupled microsomal nitric oxide dioxygenase (2004), Free Radic. Biol. Med., 37, 216-228.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
econazole
-
 Homo sapiens
ketoconazole
-
 Homo sapiens
miconazole
-
 Homo sapiens
quercetin
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0003
-
 NO
-
 Homo sapiens
0.002
-
 NADPH
-
 Homo sapiens
0.009
-
 O2
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NO + O2 + NADPH
-
 Homo sapiens NO3- + NADP+ + H+
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens