Literature summary for 1.14.12.7 extracted from

Gassner, G.T.; Ballou, D.P.; Landrum, G.A.; Whittaker, J.W.
Magnetic circular dichroism studies on the mononuclear ferrous active site of phthalate dioxygenase from Pseudomonas cepacia show a change of ligation state on substrate binding (1993), Biochemistry, 32, 4820-4825.

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Metals/Ions

Metals/Ions	Comment	Organism	Structure
Fe2+	mononuclear ferrous center is strictly required for catalytic oxygen activation, change of ligation state is associated with substrate binding	Burkholderia cepacia
Iron	enzyme contains a [2Fe-2S] Rieske cluster	Burkholderia cepacia

Organism

Organism	UniProt	Comment	Textmining
Burkholderia cepacia	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phthalate + NADH + O2	-	Burkholderia cepacia	cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ + H2O	-	?

Cofactor

Cofactor	Comment	Organism	Structure
NADH	-	Burkholderia cepacia

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Release 2023.1 (January 2023)