Cloned (Comment) | Organism |
---|---|
gene salA, quantitative RT-PCR enzyme expression analysis | Trichophyton rubrum |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of a strain with multiple copies of salA via protoplast transformations, the mutant exhibits elevated expression of salA and increased terbinafine resistance | Trichophyton rubrum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
salicylate + NADH + 2 H+ + O2 | Trichophyton rubrum | - |
catechol + NAD+ + H2O + CO2 | - |
? | |
salicylate + NADH + 2 H+ + O2 | Trichophyton rubrum CBS118892 | - |
catechol + NAD+ + H2O + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trichophyton rubrum | F2SJL1 | - |
- |
Trichophyton rubrum CBS118892 | F2SJL1 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
salicylate + NADH + 2 H+ + O2 | - |
Trichophyton rubrum | catechol + NAD+ + H2O + CO2 | - |
? | |
salicylate + NADH + 2 H+ + O2 | - |
Trichophyton rubrum CBS118892 | catechol + NAD+ + H2O + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
salA | - |
Trichophyton rubrum |
Salicylate 1-monooxygenase | - |
Trichophyton rubrum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Trichophyton rubrum | |
NADH | - |
Trichophyton rubrum |
Organism | Comment | Expression |
---|---|---|
Trichophyton rubrum | gene salA is transcriptionally upregulated in Trichophyton rubrum in response to terbinafine | up |
General Information | Comment | Organism |
---|---|---|
malfunction | a mutant strain with multiple copies of salA exhibits elevated expression of salA and increased terbinafine resistance | Trichophyton rubrum |
physiological function | the salA gene, encoding salicylate 1-monooxygenase, is involved in resistance of the dermatophyte Trichophyton rubrum to terbinafine (TRB), one of the most effective antifungal drugs against dermatophytes. Resistance to TRB is mediated by multiple salA copies in Trichophyton rubrum. Salicylate 1-monooxygenase is an enzyme that participates in the naphthalene degradation pathway, converting the intermediate metabolite salicylic acid into catechol | Trichophyton rubrum |