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Literature summary for 1.14.13.148 extracted from
- The FAD-containing monooxygenase-catalyzed N-oxidation and demethylation of trimethylamine in rat liver microsomes (1991), Drug Metabol. Drug Interact., 9, 201-208.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | enzyme reactions are not inhibited by gas phase containing up to 80% carbon monoxide/20% oxygen mixture | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N,N,N-trimethylamine + NADPH + H+ + O2 | - |
Rattus norvegicus | N,N,N-trimethylamine N-oxide + NADP+ + H2O | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FAD-containing monooxygenase | - |
Rattus norvegicus |
| FMO | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Rattus norvegicus | |
| NADPH | required for activity, in the absence of NADP or NADPH, the FAD-containing monooxygenase is irreversibly inactivated at 37°C during 30 min | Rattus norvegicus | |
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