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Literature summary for 1.14.13.149 extracted from

  • Pribytkova, T.; Lightly, T.; Kumar, B.; Bernier, S.; Sorensen, J.; Surette, M.; Cardona, S.
    The attenuated virulence of a Burkholderia cenocepacia paaABCDE mutant is due to inhibition of quorum sensing by release of phenylacetic acid (2014), Mol. Microbiol., 94, 522-536 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
paaABCDE gene cluster Burkholderia cenocepacia

Protein Variants

Protein Variants Comment Organism
additional information Burkholderia cenocepacia paaA and paaE mutants, in which the paaABCDE gene cluster is interrupted, are defective in PAA degradation and are attenuated for virulence in the nematode host model Caenorhabditis elegans. While the mutants of the PAA-CoA monooxygenase complex re attenuated for pathogenicity, mutants of the ring opening or beta-oxidation steps are not. henotypes, overview Burkholderia cenocepacia

Organism

Organism UniProt Comment Textmining
Burkholderia cenocepacia
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Burkholderia cenocepacia K56-2
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Synonyms

Synonyms Comment Organism
PaaABCDE
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 Burkholderia cenocepacia
phenylacetyl-CoA monooxygenase
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 Burkholderia cenocepacia
ring 1,2 phenylacetyl-CoA epoxidase
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 Burkholderia cenocepacia

General Information

General Information Comment Organism
malfunction inhibition of quorum sensing by release of phenylacetic acid leads to attenuated virulence of the Burkholderia cenocepacia paaABCDE mutant. Burkholderia cenocepacia paaA and paaE mutants, in which the paaABCDE gene cluster is interrupted, are defective in PAA degradation and are attenuated for virulence in the nematode host model Caenorhabditis elegans. While the mutants of the PAA-CoA monooxygenase complex re attenuated for pathogenicity, mutants of the ring opening or beta-oxidation steps are not, possibly because some by-products are required for pathogenicity but not produced in DELTApaaABCDE. Phenotypes, overview Burkholderia cenocepacia
metabolism the enzyme complex is involved in the phenylacteic acid, PAA, degradation pathway, overview Burkholderia cenocepacia
physiological function the phenylacetic acid degradation pathway of Burkholderia cenocepacia is active during cystic fibrosis-like conditions and is necessary for full pathogenicity of Burkholderia cenocepacia in nematode and rat infection models. Pathogenicity against Caenorhabditis elegans, increased with exogenous N-octanoyl-L-homoserine lactone Burkholderia cenocepacia