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Literature summary for 1.14.13.163 extracted from

  • Li, H.; Xie, K.; Yu, W.; Hu, L.; Huang, H.; Xie, H.; Wang, S.
    Nicotine dehydrogenase complexed with 6-hydroxypseudooxynicotine oxidase involved in the hybrid nicotine-degrading pathway in Agrobacterium tumefaciens S33 (2016), Appl. Environ. Microbiol., 82, 1745-1755 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.13.163

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + 2 H+ + O2 Agrobacterium tumefaciens
-
 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O
-
 ?
4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + 2 H+ + O2 Agrobacterium tumefaciens S33
-
 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Agrobacterium tumefaciens W8E0Y0
-
-
Agrobacterium tumefaciens S33 W8E0Y0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + 2 H+ + O2
-
 Agrobacterium tumefaciens 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O
-
 ?
4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + 2 H+ + O2
-
 Agrobacterium tumefaciens S33 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
6-hydroxy-3-succinoylpyridine hydroxylase
-
 Agrobacterium tumefaciens
AWN88_01205 gene name, UniProt Agrobacterium tumefaciens
Hsh
-
 Agrobacterium tumefaciens
HSP hydroxylase
-
 Agrobacterium tumefaciens

Cofactor

Cofactor Comment Organism Structure
FAD required for activity Agrobacterium tumefaciens
NADH dependent on Agrobacterium tumefaciens

General Information

General Information Comment Organism
metabolism 6-hydroxy-3-succinoylpyridine hydroxylase catalyzes a central step of nicotine degradation. 6-Hydroxy-3-succinoylpyridine (HSP) is a key intermediate connecting the two pathways, pyridine pathway and pyrrolidine pathway, detailed overview Agrobacterium tumefaciens
physiological function the key enzyme HSP hydroxylase is involved in the fused nicotine degradation pathway of the pyridine and pyrrolidine pathways Agrobacterium tumefaciens