Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + 2 H+ + O2 | Agrobacterium tumefaciens | - |
2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O | - |
? | |
4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + 2 H+ + O2 | Agrobacterium tumefaciens S33 | - |
2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Agrobacterium tumefaciens | W8E0Y0 | - |
- |
Agrobacterium tumefaciens S33 | W8E0Y0 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + 2 H+ + O2 | - |
Agrobacterium tumefaciens | 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O | - |
? | |
4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + 2 H+ + O2 | - |
Agrobacterium tumefaciens S33 | 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
6-hydroxy-3-succinoylpyridine hydroxylase | - |
Agrobacterium tumefaciens |
AWN88_01205 | gene name, UniProt | Agrobacterium tumefaciens |
Hsh | - |
Agrobacterium tumefaciens |
HSP hydroxylase | - |
Agrobacterium tumefaciens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | required for activity | Agrobacterium tumefaciens | |
NADH | dependent on | Agrobacterium tumefaciens |
General Information | Comment | Organism |
---|---|---|
metabolism | 6-hydroxy-3-succinoylpyridine hydroxylase catalyzes a central step of nicotine degradation. 6-Hydroxy-3-succinoylpyridine (HSP) is a key intermediate connecting the two pathways, pyridine pathway and pyrrolidine pathway, detailed overview | Agrobacterium tumefaciens |
physiological function | the key enzyme HSP hydroxylase is involved in the fused nicotine degradation pathway of the pyridine and pyrrolidine pathways | Agrobacterium tumefaciens |