Literature summary for 1.14.13.167 extracted from

Deng, S.; Zhang, W.; Wang, J.; Gao, Y.; Xu, Y.; Zhou, N.
Single point mutation in the transcriptional regulator PnpR renders Pseudomonas sp. strain WBC-3 capable of utilizing 2-chloro-4-nitrophenol (2019), Int. Biodeter. Biodegrad., 143, 104732 .

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Organism

Organism	UniProt	Comment	Textmining
Pseudomonas sp. WBC-3	C1I201	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-chloro-4-nitrophenol + NADPH + H+ + O2	-	Pseudomonas sp. WBC-3	2-chloro-1,4-benzoquinone + nitrite + NADP+ + H2O	-	?
4-nitrophenol + NADPH + H+ + O2	-	Pseudomonas sp. WBC-3	1,4-benzoquinone + nitrite + NAD+ + H2O	-	?

Synonyms

Synonyms	Comment	Organism
pnpA	-	Pseudomonas sp. WBC-3

General Information

General Information	Comment	Organism
physiological function	2-chloro-4-nitrophenol serves as a substrate for the 4-monooxygenase PnpA, but wild-type is unable to utilize 2-chloro-4-nitrophenol. Transcriptional regulator PnpR variant S6C drives the 4-nitrophenol-independent expression of PnpA and PnpB operons in an almost constitutive manner and allows higher levels of induction upon addition of inducers. When the pnpRS6C allele is introduced into a PnpR-deleted mutant, the corresponding strain acquires the ability to grow on 2-chloro-4-nitrophenol but is still able to utilize 4-nitrophenol for growth	Pseudomonas sp. WBC-3

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Release 2023.1 (January 2023)