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Literature summary for 1.14.13.200 extracted from
- Nucleotide sequences and heterologous expression of tcmG and tcmP, biosynthetic genes for tetracenomycin C in Streptomyces glaucescens (1993), J. Bacteriol., 175, 3876-3886.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Streptomyces lividans | Streptomyces glaucescens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces glaucescens | P39888 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| tetracenomycin A2 + 2 O2 + 2 NAD(P)H + 2 H+ | - |
Streptomyces glaucescens | tetracenomycin C + 2 NAD(P)+ + H2O | enzyme is responsible for the hydroxylation of tetracenomycin A2 at positions C-4, C-4a, and C-12a to give tetracenomycin C | ? |  |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Streptomyces glaucescens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Streptomyces glaucescens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | enzyme is responsible for the hydroxylation of tetracenomycin A2 at positions C-4, C-4a, and C-12a to give tetracenomycin C, i.e. the final step in tetracenomycin C biosynthesis | Streptomyces glaucescens |
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