Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
protodeoxyviolaceinate + NADPH + H+ + O2 | Chromobacterium violaceum | enzyme VioD is a monooxygenase catalyzing the incorporation of O2 into 6-postion | protoviolaceinate + NADP+ | - |
? | |
protodeoxyviolaceinate + NADPH + H+ + O2 | Chromobacterium violaceum JCM 1249 | enzyme VioD is a monooxygenase catalyzing the incorporation of O2 into 6-postion | protoviolaceinate + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Chromobacterium violaceum | Q9S3U8 | gene vioD in gene cluster vioABDE | - |
Chromobacterium violaceum JCM 1249 | Q9S3U8 | gene vioD in gene cluster vioABDE | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
protodeoxyviolaceinate + NADPH + H+ + O2 | enzyme VioD is a monooxygenase catalyzing the incorporation of O2 into 6-postion | Chromobacterium violaceum | protoviolaceinate + NADP+ | - |
? | |
protodeoxyviolaceinate + NADPH + H+ + O2 | VioD catalyses the oxygenation reaction at the 6-position | Chromobacterium violaceum | protoviolaceinate + NADP+ | i.e. 5-(5-hydroxy-1H-indol-3-yl)-3-(1H-indol-3-yl)-1H-pyrrole-2-carboxylic acid | ? | |
protodeoxyviolaceinate + NADPH + H+ + O2 | enzyme VioD is a monooxygenase catalyzing the incorporation of O2 into 6-postion | Chromobacterium violaceum JCM 1249 | protoviolaceinate + NADP+ | - |
? | |
protodeoxyviolaceinate + NADPH + H+ + O2 | VioD catalyses the oxygenation reaction at the 6-position | Chromobacterium violaceum JCM 1249 | protoviolaceinate + NADP+ | i.e. 5-(5-hydroxy-1H-indol-3-yl)-3-(1H-indol-3-yl)-1H-pyrrole-2-carboxylic acid | ? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Chromobacterium violaceum | |
NADPH | essentially required | Chromobacterium violaceum |
General Information | Comment | Organism |
---|---|---|
malfunction | formation of deoxyviolacein and prodeoxyviolacein occurs due to the insufficient amount of VioD | Chromobacterium violaceum |
metabolism | the enzyme is involved in the violacein biosynthetic pathway, which is proposed to consist of the reactions of enzymes VioA -> VioB -> VioE -> VioD -> VioC | Chromobacterium violaceum |