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Literature summary for 1.14.13.39 extracted from

  • Knowles, R.G.; Merrett, M.; Salter, M.; Moncada, S.
    Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat (1990), Biochem. J., 270, 833-836.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.13.39

Inhibitors

Inhibitors Comment Organism Structure
EDTA brain enzyme Rattus norvegicus
L-canavanine liver enzyme, slight inhibition of brain enzyme Rattus norvegicus
Ngamma-monomethyl-L-arginine
-
 Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ requirement, brain, not liver or lung Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 L-arginine + 3 NADPH + 4 O2 + 3 H+ Rattus norvegicus
-
 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
 ?
2 L-arginine + 3 NADPH + 4 O2 + 3 H+ Rattus norvegicus Wistar
-
 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Wistar strain
-
Rattus norvegicus
-
 2 isoforms
-
Rattus norvegicus Wistar
-
 Wistar strain
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-
lung
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 activity in lung and liver only after induction by endotoxin Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
 Rattus norvegicus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
 ?
2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
 Rattus norvegicus Wistar 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
 ?
L-homoarginine + NADPH + O2 poor substrate Rattus norvegicus ?
-
 ?
L-homoarginine + NADPH + O2 poor substrate Rattus norvegicus Wistar ?
-
 ?
additional information D-arginine is no substrate Rattus norvegicus ?
-
 ?
additional information D-arginine is no substrate Rattus norvegicus Wistar ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus