Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.13.39 extracted from

  • Ohshima, H.; Oguchi, S.; Adachi, H.; Iida, S.; Suzuki, H.; Sugimura, T.; Esumi, H.
    Purification of nitric oxide synthase from bovine brain: immunological characterization and tissue distribution (1992), Biochem. Biophys. Res. Commun., 183, 238-244.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Ngamma-monomethyl-L-arginine
-
Bos taurus
Ngamma-monomethyl-L-arginine
-
Rattus norvegicus
Ngamma-nitro-L-arginine
-
Bos taurus
Ngamma-nitro-L-arginine
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0004
-
NADPH
-
Bos taurus
0.002 0.0028 L-arginine
-
Rattus norvegicus
0.002 0.0028 L-arginine
-
Bos taurus
0.0023
-
L-arginine
-
Bos taurus
0.0033 0.0043 L-arginine
-
Rattus norvegicus
0.0033 0.0043 L-arginine NADPH, bovine Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
Rattus norvegicus
Ca2+
-
Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
150000
-
1 * 150000, SDS-PAGE Rattus norvegicus
150000
-
1 * 150000, SDS-PAGE Bos taurus
150000
-
2 * 150000, SDS-PAGE, gel filtration at high salt concentration Bos taurus
300000
-
gel filtration Rattus norvegicus
300000
-
gel filtration Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Rattus norvegicus
-
Sprague-Dawley
-
Rattus norvegicus Sprague-Dawley
-
Sprague-Dawley
-

Purification (Commentary)

Purification (Comment) Organism
affinity chromatography Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
Rattus norvegicus
-
adrenal gland
-
Bos taurus
-
brain
-
Rattus norvegicus
-
brain
-
Bos taurus
-
brain stem cerebrum shows higher activity than cerebellum Rattus norvegicus
-
brain stem cerebrum shows higher activity than cerebellum Bos taurus
-
cerebellum
-
Rattus norvegicus
-
cerebellum
-
Bos taurus
-
cerebrum
-
Rattus norvegicus
-
cerebrum
-
Bos taurus
-
pituitary gland
-
Rattus norvegicus
-
pituitary gland
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.34 0.35
-
Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
Rattus norvegicus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?
2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
Bos taurus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?
2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
Rattus norvegicus Sprague-Dawley 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?

Subunits

Subunits Comment Organism
dimer
-
Rattus norvegicus
dimer 2 * 150000, SDS-PAGE, gel filtration at high salt concentration Bos taurus
monomer 1 * 150000, SDS-PAGE Rattus norvegicus
monomer 1 * 150000, SDS-PAGE Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus
37
-
assay at Bos taurus

Cofactor

Cofactor Comment Organism Structure
5,6,7,8-tetrahydro-L-biopterin
-
Rattus norvegicus
5,6,7,8-tetrahydro-L-biopterin
-
Bos taurus
Calmodulin
-
Rattus norvegicus
Calmodulin
-
Bos taurus
NADPH
-
Rattus norvegicus
NADPH
-
Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0015
-
Ngamma-nitro-L-arginine
-
Bos taurus
0.0025
-
Ngamma-monomethyl-L-arginine
-
Bos taurus