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Literature summary for 1.14.13.39 extracted from

  • Kim, J.; Park, H.; Myung-Hyun, J.; Han, S.H.; Chung, H.; Lee, J.S.; Park, J.S.; Yoon, M.Y.
    The effects of anthrax lethal factor on the macrophage proteome: potential activity on nitric oxide synthases (2008), Arch. Biochem. Biophys., 472, 58-64.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information anthrax lethal factor potentially cleaves the regions (L191-Q192 and D264-N265) close to the NH2-terminus of neuronal nitric oxide synthase; inducible nitric oxide synthase is resistant to anthrax lethal factor-mediated cleavage Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P29476
-
-
Rattus norvegicus Q06518
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain nNOS is the predominant isozyme in brain Rattus norvegicus
-
macrophage iNOS is the predominant isozyme in macrophages Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-arginine + 3 NADPH + 3 H+ + 4 O2
-
Rattus norvegicus 2 citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
-
?

Synonyms

Synonyms Comment Organism
inducible NO synthase
-
Rattus norvegicus
iNOS
-
Rattus norvegicus
neuronal NO synthase
-
Rattus norvegicus
nNOS
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Rattus norvegicus