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Literature summary for 1.14.13.39 extracted from

  • Rosa, S.C.; Judas, F.; Lopes, M.C.; Mendes, A.F.
    Nitric oxide synthase isoforms and NF-kappaB activity in normal and osteoarthritic human chondrocytes: regulation by inducible nitric oxide (2008), Nitric Oxide, 19, 276-283.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information interleukin-1 induces the degradation of isozyme iNOS, iNOS protein levels in osteoarthritic chondrocytes decreases to 45.4% of the control upon treatment with interleukin-1 for 15 min, and are further reduced to 41.5% when the treatment period is extended to 2 h; tissue necrosis factor-alpha induces nNOS disappearance, interleukin-1 induces the degradation of nNOS Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
15000
-
x * 15000, SDS-PAGE Homo sapiens
150000
-
SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P29475
-
-
Homo sapiens P35228
-
-

Source Tissue

Source Tissue Comment Organism Textmining
chondrocyte iNOS is more frequently expressed in osteoarthritic than in normal chondrocytes, iNOS expression and activity in osteoarthritic chondrocytes is sub-maximal Homo sapiens
-
chondrocyte nNOS is more frequently expressed in normal than in osteoarthritic chondrocytes Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-arginine + 3 NADPH + 3 H+ + 4 O2
-
Homo sapiens 2 citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
-
?

Subunits

Subunits Comment Organism
? x * 15000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
inducible NO synthase
-
Homo sapiens
iNOS isoform Homo sapiens
neuronal NO synthase
-
Homo sapiens
nNOS isoform Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens neither interleukin-1 nor tissue necrosis factor-alpha is capable of inducing nNOS synthesis for up to 48 h treatment, treatment with insulin-like growth factor-1 or transforming growth factor-beta for up to 48 h has no effect on the levels of nNOS additional information
Homo sapiens treatment with insulin-like growth factor-1 or transforming growth factor-beta for up to 48 h has no effect on the levels of iNOS additional information
Homo sapiens treatment with interleukin-1 or tissue necrosis factor-alpha for 16 h significantly increases iNOS levels to 429.4% of the control up