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Literature summary for 1.14.13.50 extracted from

  • Crawford, R.L.; Jung, C.M.; Strap, J.L.
    The recent evolution of pentachlorophenol (PCP)-4-monooxygenase (PcpB) and associated pathways for bacterial degradation of PCP (2006), Biodegradation, 18, 525-539.
    View publication on PubMed
Search for more literature for 1.14.13.50

Application

Application Comment Organism
additional information the enzyme can be used for development of a model system for the study of recent evolution of catabolic pathways among bacteria that degrade xenobiotic molecules introduced into the environment during the recent past Sphingomonas sp.
additional information the enzyme can be used for development of a model system for the study of recent evolution of catabolic pathways among bacteria that degrade xenobiotic molecules introduced into the environment during the recent past Sphingobium chlorophenolicum
additional information the enzyme can be used for development of a model system for the study of recent evolution of catabolic pathways among bacteria that degrade xenobiotic molecules introduced into the environment during the recent past Mycolicibacterium chlorophenolicum

Cloned(Commentary)

Cloned (Comment) Organism
gene pcpB, DNA and amino acid sequence analysis, phylogenetic analysis Sphingomonas sp.
gene pcpB, DNA and amino acid sequence analysis, phylogenetic analysis Sphingobium chlorophenolicum
gene pcpB, DNA and amino acid sequence analysis, phylogenetic analysis Mycolicibacterium chlorophenolicum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Sphingomonas sp. lateral gene transfer and the origin of the pentachlorophenol pathway, overview ?
-
 ?
additional information Sphingobium chlorophenolicum lateral gene transfer and the origin of the pentachlorophenol pathway, overview ?
-
 ?
additional information Mycolicibacterium chlorophenolicum lateral gene transfer and the origin of the pentachlorophenol pathway, overview ?
-
 ?
pentachlorophenol + NADPH + H+ + O2 Sphingomonas sp. initial enzyme in the PCP catabolic pathway of numerous sphingomonads, PCP-4-monooxygenase (PcpB), catalyzes the parahydroxylation of PCP to tetrachlorohydroquinone, pentachlorophenol degradation pathway, overview 2,3,5,6-tetrachlorohydroquinone + NADP+ + chloride + H2O
-
 ?
pentachlorophenol + NADPH + H+ + O2 Sphingobium chlorophenolicum initial enzyme in the PCP catabolic pathway of numerous sphingomonads, PCP-4-monooxygenase (PcpB), catalyzes the parahydroxylation of PCP to tetrachlorohydroquinone, pentachlorophenol degradation pathway, overview 2,3,5,6-tetrachlorohydroquinone + NADP+ + chloride + H2O
-
 ?
pentachlorophenol + NADPH + H+ + O2 Mycolicibacterium chlorophenolicum initial enzyme in the PCP catabolic pathway of numerous sphingomonads, PCP-4-monooxygenase (PcpB), catalyzes the parahydroxylation of PCP to tetrachlorohydroquinone, pentachlorophenol degradation pathway, overview 2,3,5,6-tetrachlorohydroquinone + NADP+ + chloride + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Mycolicibacterium chlorophenolicum
-
 i.e. Mycobacterium chlorophenolicus, gene pcpB
-
Sphingobium chlorophenolicum
-
 i.e. Pseudomonas sp. RA2 and Pseudomonas sp. SR3, and Arthrobacter sp. strain ATCC 33790, gene pcpB
-
Sphingobium chlorophenolicum
-
 strain ATCC 39723, formerly Flavobacterium and Sphingomonas, gene pcpB
-
Sphingomonas sp.
-
 ssp. UG25 and UG30, gene pcpB
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,3,4,6-tetrachlorophenol + NADPH + O2
-
 Mycolicibacterium chlorophenolicum ?
-
 ?
2,3,5,6-tetrachlorophenol + NADPH + O2
-
 Sphingobium chlorophenolicum ?
-
 ?
2,3,5,6-tetrachlorophenol + NADPH + O2
-
 Mycolicibacterium chlorophenolicum ?
-
 ?
2,3,5-trichlorophenol + NADPH + O2
-
 Mycolicibacterium chlorophenolicum ?
-
 ?
2,3,6-trichlorophenol + NADPH + O2
-
 Sphingobium chlorophenolicum ?
-
 ?
2,3,6-trichlorophenol + NADPH + O2
-
 Mycolicibacterium chlorophenolicum ?
-
 ?
2,4,6-trichlorophenol + NADPH + O2
-
 Sphingobium chlorophenolicum ?
-
 ?
2,4-dichlorophenol + NADPH + O2
-
 Sphingobium chlorophenolicum ?
-
 ?
2,4-dinitrophenol + NADPH + O2
-
 Sphingomonas sp. ?
-
 ?
2,6-dichlorophenol + NADPH + O2
-
 Sphingobium chlorophenolicum ?
-
 ?
3,4,5,6-tetrachlorophenol + NADPH + O2
-
 Mycolicibacterium chlorophenolicum ?
-
 ?
3,4,5-trichlorophenol + NADPH + O2
-
 Mycolicibacterium chlorophenolicum ?
-
 ?
3,5-dibromo-4-hydroxybenzonitrile + NADPH + O2
-
 Sphingobium chlorophenolicum ?
-
 ?
4,6-dinitro-o-cresol + NADPH + O2
-
 Sphingomonas sp. ?
-
 ?
4-nitrocatechol + NADPH + O2
-
 Sphingomonas sp. ?
-
 ?
4-nitrophenol + NADPH + O2
-
 Sphingomonas sp. ?
-
 ?
chloroguaiacol + NADPH + O2
-
 Mycolicibacterium chlorophenolicum ?
-
 ?
additional information lateral gene transfer and the origin of the pentachlorophenol pathway, overview Sphingomonas sp. ?
-
 ?
additional information lateral gene transfer and the origin of the pentachlorophenol pathway, overview Sphingobium chlorophenolicum ?
-
 ?
additional information lateral gene transfer and the origin of the pentachlorophenol pathway, overview Mycolicibacterium chlorophenolicum ?
-
 ?
pentachlorophenol + NADPH + H+ + O2
-
 Sphingomonas sp. 2,3,5,6-tetrachlorohydroquinone + NADP+ + chloride + H2O
-
 ?
pentachlorophenol + NADPH + H+ + O2
-
 Sphingobium chlorophenolicum 2,3,5,6-tetrachlorohydroquinone + NADP+ + chloride + H2O
-
 ?
pentachlorophenol + NADPH + H+ + O2
-
 Mycolicibacterium chlorophenolicum 2,3,5,6-tetrachlorohydroquinone + NADP+ + chloride + H2O
-
 ?
pentachlorophenol + NADPH + H+ + O2 initial enzyme in the PCP catabolic pathway of numerous sphingomonads, PCP-4-monooxygenase (PcpB), catalyzes the parahydroxylation of PCP to tetrachlorohydroquinone, pentachlorophenol degradation pathway, overview Sphingomonas sp. 2,3,5,6-tetrachlorohydroquinone + NADP+ + chloride + H2O
-
 ?
pentachlorophenol + NADPH + H+ + O2 initial enzyme in the PCP catabolic pathway of numerous sphingomonads, PCP-4-monooxygenase (PcpB), catalyzes the parahydroxylation of PCP to tetrachlorohydroquinone, pentachlorophenol degradation pathway, overview Sphingobium chlorophenolicum 2,3,5,6-tetrachlorohydroquinone + NADP+ + chloride + H2O
-
 ?
pentachlorophenol + NADPH + H+ + O2 initial enzyme in the PCP catabolic pathway of numerous sphingomonads, PCP-4-monooxygenase (PcpB), catalyzes the parahydroxylation of PCP to tetrachlorohydroquinone, pentachlorophenol degradation pathway, overview Mycolicibacterium chlorophenolicum 2,3,5,6-tetrachlorohydroquinone + NADP+ + chloride + H2O
-
 ?
tribromophenol + NADPH + O2
-
 Sphingobium chlorophenolicum ?
-
 ?
triiodophenol + NADPH + O2
-
 Sphingobium chlorophenolicum ?
-
 ?
Tween 20 + NADPH + O2
-
 Sphingobium chlorophenolicum ?
-
 ?

Synonyms

Synonyms Comment Organism
PCP-4-monooxygenase
-
 Sphingomonas sp.
PCP-4-monooxygenase
-
 Sphingobium chlorophenolicum
PCP-4-monooxygenase
-
 Mycolicibacterium chlorophenolicum
PcpB
-
 Sphingomonas sp.
PcpB
-
 Sphingobium chlorophenolicum
PcpB
-
 Mycolicibacterium chlorophenolicum
pentachlorophenol-4-monooxygenase
-
 Sphingomonas sp.
pentachlorophenol-4-monooxygenase
-
 Sphingobium chlorophenolicum
pentachlorophenol-4-monooxygenase
-
 Mycolicibacterium chlorophenolicum

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Sphingomonas sp.
NADPH
-
 Sphingobium chlorophenolicum
NADPH
-
 Mycolicibacterium chlorophenolicum