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Literature summary for 1.14.13.8 extracted from

  • Klick, D.E.; Shadley, J.D.; Hines, R.N.
    Differential regulation of human hepatic flavin containing monooxygenase 3 (FMO3) by CCAAT/enhancer-binding protein beta (C/EBPbeta) liver inhibitory and liver activating proteins (2008), Biochem. Pharmacol., 76, 268-278.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene FMO3, DNA and amino acid sequence determination and analysis, transient expression in Hep-G2 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information the HepG2 model is suitable for the study of FMO3 regulation, deletion analysis of FMO3/luciferase reporter constructs, domains A-I, and specific transcription factor responsive elements identified by DNA-protein binding reactions and site-directed mutagenesis of FMO3 reporter constructs, functional analysis of the FMO3 HNF3, and C/EBP elements, FMO3 promoter analysis, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens human FMO3 regulatory elements, overview ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens P31513 FMO3; gene FMO3
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Source Tissue

Source Tissue Comment Organism Textmining
liver
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Homo sapiens
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additional information no expression of FMO3 in Hep-G2 cells, decreased hepatic nuclear factor HNF4alpha levels and DNA hypermethylation are the mechanisms suppressing Hep-G2 FMO3 expression Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information human FMO3 regulatory elements, overview Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
flavin containing monooxygenase 3
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Homo sapiens
FMO3
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Homo sapiens