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Literature summary for 1.14.13.8 extracted from

  • Uehara, S.; Uno, Y.; Inoue, T.; Murayama, N.; Shimizu, M.; Sasaki, E.; Yamazaki, H.
    Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus) (2015), Drug Metab. Dispos., 43, 735-742 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Callithrix jacchus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.137
-
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine isoform FMO3, pH and temperature not specified in the publication Callithrix jacchus

Organism

Organism UniProt Comment Textmining
Callithrix jacchus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + NADPH + H+ + O2
-
Callithrix jacchus 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine N-oxide + NADP+ + H2O
-
?
benzydamine + NADPH + H+ + O2
-
Callithrix jacchus benzydamine N-oxide + NADP+ + H2O
-
?

Synonyms

Synonyms Comment Organism
FMO3 isoform Callithrix jacchus

Cofactor

Cofactor Comment Organism Structure
FAD
-
Callithrix jacchus
NADPH
-
Callithrix jacchus