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Literature summary for 1.14.13.8 extracted from

  • Taniguchi-Takizawa, T.; Shimizu, M.; Kume, T.; Yamazaki, H.
    Benzydamine N-oxygenation as an index for flavin-containing monooxygenase activity and benzydamine N-demethylation by cytochrome P450 enzymes in liver microsomes from rats, dogs, monkeys, and humans (2015), Drug Metab. Pharmacokinet., 30, 64-69 .
    View publication on PubMed
Search for more literature for 1.14.13.8

Inhibitors

Inhibitors Comment Organism Structure
1-aminobenzotriazole about 20% inhibition at 2 mM Canis lupus familiaris
1-aminobenzotriazole about 20% inhibition at 2 mM Homo sapiens
1-aminobenzotriazole about 20% inhibition at 2 mM Macaca fascicularis
1-aminobenzotriazole about 20% inhibition at 2 mM Rattus norvegicus
dimethyl sulfoxide about 50% inhibition at 0.5 % (v/v) Canis lupus familiaris
dimethyl sulfoxide about 50% inhibition at 0.5 % (v/v) Homo sapiens
dimethyl sulfoxide about 50% inhibition at 0.5 % (v/v) Macaca fascicularis
dimethyl sulfoxide about 50% inhibition at 0.5 % (v/v) Rattus norvegicus
Methimazole about 90% inhibition at 0.2 mM Canis lupus familiaris
Methimazole about 90% inhibition at 0.2 mM Homo sapiens
Methimazole about 90% inhibition at 0.2 mM Macaca fascicularis
Methimazole about 90% inhibition at 0.2 mM Rattus norvegicus
additional information not inhibited by methanol Canis lupus familiaris
additional information not inhibited by methanol Homo sapiens
additional information not inhibited by methanol Macaca fascicularis
additional information not inhibited by methanol Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-
microsome
-
 Rattus norvegicus
-
-
microsome
-
 Canis lupus familiaris
-
-
microsome
-
 Macaca fascicularis
-
-

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-
Homo sapiens
-
-
-
Macaca fascicularis
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-
liver
-
 Canis lupus familiaris
-
liver
-
 Macaca fascicularis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzydamine + NADPH + H+ + O2
-
 Homo sapiens benzydamine N-oxide + NADP+ + H2O
-
 ?
benzydamine + NADPH + H+ + O2
-
 Rattus norvegicus benzydamine N-oxide + NADP+ + H2O
-
 ?
benzydamine + NADPH + H+ + O2
-
 Canis lupus familiaris benzydamine N-oxide + NADP+ + H2O
-
 ?
benzydamine + NADPH + H+ + O2
-
 Macaca fascicularis benzydamine N-oxide + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
FMO1 isoform Homo sapiens
FMO1 isoform Rattus norvegicus
FMO1 isoform Canis lupus familiaris
FMO1 isoform Macaca fascicularis
FMO3 isoform Homo sapiens
FMO3 isoform Rattus norvegicus
FMO3 isoform Canis lupus familiaris
FMO3 isoform Macaca fascicularis

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
45
-
 the benzydamine N-oxygenation activity of the enzyme is reduced by approximately 70% by preheating at 45°C for 5 min. Benzydamine N-oxygenation is suppressed by 30% and 50% after preincubation of liver microsomes at 37°C for 5 and 10 min, respectively Homo sapiens
45
-
 the benzydamine N-oxygenation activity of the enzyme is reduced by approximately 70% by preheating at 45°C for 5 min. Benzydamine N-oxygenation is suppressed by 30% and 50% after preincubation of liver microsomes at 37°C for 5 and 10 min, respectively Macaca fascicularis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.4
-
-
 Homo sapiens
8.4
-
-
 Macaca fascicularis

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Homo sapiens
FAD
-
 Rattus norvegicus
FAD
-
 Canis lupus familiaris
FAD
-
 Macaca fascicularis
NADPH
-
 Homo sapiens
NADPH
-
 Rattus norvegicus
NADPH
-
 Canis lupus familiaris
NADPH
-
 Macaca fascicularis