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Literature summary for 1.14.13.8 extracted from
- The molecular mechanism regulating diurnal rhythm of flavin-containing monooxygenase 5 in mouse liver (2019), Drug Metab. Dispos., 47, 1333-1342 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene Fmo5, FMO5 is located at 1q21.1 on chromosome 5, quantitative enzyme expression analysis | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Mus musculus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P97872 | - |
- |
| Mus musculus C57BL/6 | P97872 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| preparation of liver microsomes | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEPA 1-6 cell | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | in vitro microsomal Baeyer-Villiger oxidation of pentoxifylline (PTX) by Fmo5 | Mus musculus | ? | - |
- |
 |
| additional information | in vitro microsomal Baeyer-Villiger oxidation of pentoxifylline (PTX) by Fmo5 | Mus musculus C57BL/6 | ? | - |
- |
|
| pentoxifylline + NADPH + H+ + O2 | - |
Mus musculus | pentoxifylline N-oxide + NADP+ + H2O | - |
? | |
| pentoxifylline + NADPH + H+ + O2 | - |
Mus musculus C57BL/6 | pentoxifylline N-oxide + NADP+ + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| flavin-containing monooxygenase 5 | - |
Mus musculus |
| FMO5 | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Mus musculus | |
| NADPH | - |
Mus musculus | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | analysis of the diurnal rhythms of Fmo5 expression and activity in mouse liver and of the potential roles of clock genes (Bmal1, Rev-erba, and E4bp4) in the generation of diurnal rhythms. Fmo5 mRNA and protein show robust diurnal rhythms, with peak values at zeitgeber time (ZT) 10/14 and trough values at ZT2/22 in mouse liver. Bmal1 (a known Rev-erba activator) activates Fmo5 transcription via direct binding to an E-box (21822/21816 bp) in the promoter, whereas E4bp4 (a known Rev-erba target gene) inhibits Fmo5 transcription by binding to two D-boxes (21726/21718 and 2804/2796 bp). In conclusion, circadian clock genes control diurnal expression of Fmo5 through transcriptional actions on E-box and D-box cis-elements | down |
| Mus musculus | analysis of the diurnal rhythms of Fmo5 expression and activity in mouse liver and of the potential roles of clock genes (Bmal1, Rev-erba, and E4bp4) in the generation of diurnal rhythms. Fmo5 mRNA and protein show robust diurnal rhythms, with peak values at zeitgeber time (ZT) 10/14 and trough values at ZT2/22 in mouse liver. Bmal1 (a known Rev-erba activator) activates Fmo5 transcription via direct binding to an E-box (21822/21816 bp) in the promoter, whereas E4bp4 (a known Rev-erba target gene) inhibits Fmo5 transcription by binding to two D-boxes (21726/21718 and 2804/2796 bp). In conclusion, circadian clock genes control diurnal expression of Fmo5 through transcriptional actions on E-box and D-box cis-elements | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | flavin-containing monooxygenases (FMOs) are a family of phase I enzymes involved in metabolism of numerous drugs (e.g. benzydamine, methimazole, and albendazole) and environmental toxicants (e.g. insecticides, fonfos, and aldicarb). Flavin-containing monooxygenase 5 (FMO5) is a phase I enzyme that plays an important role in xenobiotic metabolism. Analysis of the diurnal rhythms of Fmo5 expression and activity in mouse liver and of the potential roles of clock genes (Bmal1, Rev-erba, and E4bp4) in the generation of diurnal rhythms. Fmo5 mRNA and protein show robust diurnal rhythms, with peak values at zeitgeber time (ZT) 10/14 and trough values at ZT2/22 in mouse liver. Bmal1 (a known Rev-erba activator) activates Fmo5 transcription via direct binding to an E-box (21822/21816 bp) in the promoter, whereas E4bp4 (a known Rev-erba target gene) inhibits Fmo5 transcription by binding to two D-boxes (21726/21718 and 2804/2796 bp). In conclusion, circadian clock genes control diurnal expression of Fmo5 through transcriptional actions on E-box and D-box cis-elements. Circadian time-dependent in vivo activity of Fmo5, molecular mechanism for generation of rhythmic Fmo5 expression, detailed overview. Human FMO5 specifically catalyzes the formation of an oxidized metabolite (PTX-M) from PTX, also known as a Baeyer-Villiger oxidation reaction | Mus musculus |
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