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Literature summary for 1.14.13.8 extracted from
- Flavin-containing monooxygenase 1 catalyzes the production of taurine from hypotaurine (2020), Drug Metab. Dispos., 48, 378-385 .
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of Fmo1-/-, 2-/-, and 4-/- knockout mutants, 1D 1H NMR spectroscopy to compare the urinary metabolite profiles of the knockout-mouse line and wild-type animals, metabolic profiles of hypotaurine and taurine in wild-type and mutant mice' urine samples, overview | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
| membrane | - |
Mus musculus | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| hypotaurine + NADH + H+ + O2 | Homo sapiens | S-oxygenation | taurine + NAD+ + H2O | - |
? |  |
| hypotaurine + NADH + H+ + O2 | Mus musculus | S-oxygenation | taurine + NAD+ + H2O | - |
? | |
| hypotaurine + NADPH + H+ + O2 | Homo sapiens | S-oxygenation | taurine + NADP+ + H2O | - |
? | |
| hypotaurine + NADPH + H+ + O2 | Mus musculus | S-oxygenation | taurine + NADP+ + H2O | - |
? | |
| N,N-dimethylaniline + NADPH + H+ + O2 | Homo sapiens | - |
N,N-dimethylaniline N-oxide + NADP+ + H2O | - |
? | |
| N,N-dimethylaniline + NADPH + H+ + O2 | Mus musculus | - |
N,N-dimethylaniline N-oxide + NADP+ + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Homo sapiens | Q01740 | - |
- |
| Mus musculus | P50285 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| brain | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| hypotaurine + NADH + H+ + O2 | S-oxygenation | Homo sapiens | taurine + NAD+ + H2O | - |
? | |
| hypotaurine + NADH + H+ + O2 | S-oxygenation | Mus musculus | taurine + NAD+ + H2O | - |
? | |
| hypotaurine + NADPH + H+ + O2 | S-oxygenation | Homo sapiens | taurine + NADP+ + H2O | - |
? | |
| hypotaurine + NADPH + H+ + O2 | S-oxygenation | Mus musculus | taurine + NADP+ + H2O | - |
? | |
| hypotaurine + O2 + NADH + H+ | - |
Homo sapiens | taurine + NAD+ + H2O | - |
? | |
| hypotaurine + O2 + NADPH + H+ | - |
Homo sapiens | taurine + NADP+ + H2O | - |
? | |
| methimazole + NADH + H+ | - |
Homo sapiens | ? | - |
? | |
| methimazole + NADPH + H+ | - |
Homo sapiens | ? | - |
? | |
| methimazole + NADPH + H+ + O2 | S-oxygenation | Homo sapiens | methimazole S-oxide + NADP+ + H2O | - |
? | |
| methimazole + NADPH + H+ + O2 | S-oxygenation | Mus musculus | methimazole S-oxide + NADP+ + H2O | - |
? | |
| additional information | human FMO1 catalyzes the oxygenation of hypotaurine in vitro. Ability of hypotaurine to act as a competitor substrate of FMO1 is assessed by measuring the effect of various concentrations of hypotaurine on FMO1-catalyzed S-oxygenation of methimazole | Homo sapiens | ? | - |
- |
|
| N,N-dimethylaniline + NADPH + H+ + O2 | - |
Homo sapiens | N,N-dimethylaniline N-oxide + NADP+ + H2O | - |
? | |
| N,N-dimethylaniline + NADPH + H+ + O2 | - |
Mus musculus | N,N-dimethylaniline N-oxide + NADP+ + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| flavin-containing monooxygenase 1 | - |
Homo sapiens |
| flavin-containing monooxygenase 1 | - |
Mus musculus |
| FMO1 | - |
Homo sapiens |
| FMO1 | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
| 37 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
assay at | Homo sapiens |
| 8.5 | - |
assay at | Mus musculus |
| 8.5 | - |
most active at pH 8.5 with NADPH as cofactor | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Homo sapiens | |
| FAD | - |
Mus musculus | |
| additional information | enzyme FMO1 can use either NADPH or NADH as cofactor | Homo sapiens | |
| additional information | enzyme FMO1 can use either NADPH or NADH as cofactor | Mus musculus | |
| NADH | - |
Homo sapiens | |
| NADH | - |
Mus musculus | |
| NADH | whereas NADPH is the more effective cofactor at pH 8.5, the cofactors are equally effective at pH 7.4 | Homo sapiens | |
| NADPH | - |
Homo sapiens | |
| NADPH | - |
Mus musculus | |
| NADPH | whereas NADPH is the more effective cofactor at pH 8.5, the cofactors are equally effective at pH 7.4 | Homo sapiens | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | FMO1 malfunction causes taurine deficiency, which is implicated in a number of pathologic conditions, including cardiomyopathy, muscular abnormalities, and renal dysfunction | Homo sapiens |
| malfunction | FMO1 malfunction causes taurine deficiency, which is implicated in a number of pathologic conditions, including cardiomyopathy, muscular abnormalities, and renal dysfunction | Mus musculus |
| physiological function | the formation of taurine from hypotaurine is catalyzed by an FMO in vivo, it is the terminal step of the biosynthetic pathway of taurine production from cysteine | Homo sapiens |
| physiological function | the formation of taurine from hypotaurine is catalyzed by an FMO in vivo, it is the terminal step of the biosynthetic pathway of taurine production from cysteine | Mus musculus |
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Release 2023.1 (January 2023)
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