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Literature summary for 1.14.13.9 extracted from
- Localisation of indoleamine 2,3-dioxygenase and kynurenine hydroxylase in the human placenta and decidua: implications for role of the kynurenine pathway in pregnancy (2005), Placenta, 26, 498-504.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-kynurenine + NADPH + O2 | Homo sapiens | function of the enzyme may change from a role in immunosuppression at the maternal-fetal interface in early pregnancy to one associated with regulation of fetoplacental blood flow or placental metabolism in late gestation | 3-hydroxy-L-kynurenine + NADP+ + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood vessel | villous, endothel | Homo sapiens | - |
| endothelium | vascular, of villous blood vessels | Homo sapiens | - |
| epithelium | placental | Homo sapiens | - |
| macrophage | in first and second trimester of the placenta, within the fetal villus | Homo sapiens | - |
| additional information | localization in placenta, overview | Homo sapiens | - |
| placenta | especially in stromal and glandular epithelium in the first trimester decidua | Homo sapiens | - |
| stromal cell | in first and second trimester of the placenta | Homo sapiens | - |
| syncytiotrophoblast | in first and second trimester of the placenta | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-kynurenine + NADPH + O2 | - |
Homo sapiens | 3-hydroxy-L-kynurenine + NADP+ + H2O | - |
? | |
| L-kynurenine + NADPH + O2 | function of the enzyme may change from a role in immunosuppression at the maternal-fetal interface in early pregnancy to one associated with regulation of fetoplacental blood flow or placental metabolism in late gestation | Homo sapiens | 3-hydroxy-L-kynurenine + NADP+ + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| KYN-OHase | - |
Homo sapiens |
| kynurenine hydroxylase | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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