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Literature summary for 1.14.13.9 extracted from

  • Connor, T.J.; Starr, N.; OSullivan, J.B.; Harkin, A.
    Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: a role for IFN-gamma? (2008), Neurosci. Lett., 441, 29-34.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information a systemic inflammatory challenge stimulates KMO expression in brain, increased enzyme expression is observed in rat brain 24 h post lipopolysaccharide treatment, without any change in kynurenine aminotransferase II expression Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the enzyme is responsible for driving formation of neurotoxic and neuroprotective kynurenine metabolites, regulation mechanism, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 male Sprague–Dawley rats
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Rattus norvegicus
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central nervous system
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 Rattus norvegicus
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glial cell
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 Rattus norvegicus
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additional information enzyme expression analysis in untreated and in brain after induction of inflammation, overview Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is responsible for driving formation of neurotoxic and neuroprotective kynurenine metabolites, regulation mechanism, overview Rattus norvegicus ?
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 ?

Synonyms

Synonyms Comment Organism
KMO
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 Rattus norvegicus