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Literature summary for 1.14.14.1 extracted from
- Detection of toxic effects of Cd(2+) on different fish species via liver cytochrome P450-dependent monooxygenase activities and FTIR spectroscopy (2006), Anal. Bioanal. Chem., 385, 652-659.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Cd2+ | activation of aminopyrene-N-demethylase activity of CYP2B or CYP3A isoenzymes, which is increased 3- to 4-fold | Silurus glanis |  |
| Cd2+ | activation of aminopyrene-N-demethylase activity of CYP2B or CYP3A isoenzymes, which is increased 3- to 4-fold | Hypophthalmichthys molitrix | |
| additional information | induction of CYP1A by beta-naphthoflavone | Cyprinus carpio | |
| additional information | induction of CYP1A by beta-naphthoflavone | Silurus glanis | |
| additional information | induction of CYP1A by beta-naphthoflavone | Hypophthalmichthys molitrix |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Cd2+ | strong inhibition of 7-ethoxyresorufin-O-deethylase, EROD, and a lower inhibition of 7-ethoxycoumarin-O-deethylase, ECOD, activity, cadmium causes damage to the protein structure | Cyprinus carpio | |
| Cd2+ | strong inhibition of 7-ethoxyresorufin-O-deethylase, EROD, and a lower inhibition of 7-ethoxycoumarin-O-deethylase, ECOD, activity, cadmium causes damage to the protein structure | Hypophthalmichthys molitrix | |
| Cd2+ | strong inhibition of 7-ethoxyresorufin-O-deethylase, EROD, and a lower inhibition of 7-ethoxycoumarin-O-deethylase, ECOD, activity, cadmium causes damage to the protein structure | Silurus glanis | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Cyprinus carpio | - |
- |
| microsome | - |
Silurus glanis | - |
- |
| microsome | - |
Hypophthalmichthys molitrix | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 7-ethoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2 | Cyprinus carpio | 7-ethoxycoumarin O-deethylation | ? | - |
? | |
| 7-ethoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2 | Silurus glanis | 7-ethoxycoumarin O-deethylation | ? | - |
? | |
| 7-ethoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2 | Hypophthalmichthys molitrix | 7-ethoxycoumarin O-deethylation | ? | - |
? | |
| 7-ethoxyresorufin + [reduced NADPH-hemoprotein reductase] + O2 | Cyprinus carpio | 7-ethoxyresorufin O-deethylation | ? | - |
? | |
| 7-ethoxyresorufin + [reduced NADPH-hemoprotein reductase] + O2 | Silurus glanis | 7-ethoxyresorufin O-deethylation | ? | - |
? | |
| 7-ethoxyresorufin + [reduced NADPH-hemoprotein reductase] + O2 | Hypophthalmichthys molitrix | 7-ethoxyresorufin O-deethylation | ? | - |
? | |
| aminopyrine + [reduced NADPH-hemoprotein reductase] + O2 | Cyprinus carpio | aminopyrene-N-demethylation | ? + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| aminopyrine + [reduced NADPH-hemoprotein reductase] + O2 | Silurus glanis | aminopyrene-N-demethylation | ? + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| aminopyrine + [reduced NADPH-hemoprotein reductase] + O2 | Hypophthalmichthys molitrix | aminopyrene-N-demethylation | ? + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cyprinus carpio | - |
- |
- |
| Hypophthalmichthys molitrix | - |
silver carp | - |
| Silurus glanis | - |
wels | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partially by microsome preparation | Cyprinus carpio |
| partially by microsome preparation | Silurus glanis |
| partially by microsome preparation | Hypophthalmichthys molitrix |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Cyprinus carpio | - |
| liver | - |
Silurus glanis | - |
| liver | - |
Hypophthalmichthys molitrix | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.00000002 | - |
liver microsomes, 7-ethoxycoumarin-O-deethylase activity, in presence of 0.12 mM Cd2+ | Hypophthalmichthys molitrix |
| 0.00000003 | - |
liver microsomes, 7-ethoxyresorufin-O-deethylase activity, in presence of 0.12 mM Cd2+ | Silurus glanis |
| 0.000000034 | - |
liver microsomes, 7-ethoxycoumarin-O-deethylase activity, in presence of 0.12 mM Cd2+ | Silurus glanis |
| 0.000000037 | - |
liver microsomes, aminopyrene-N-demethylation activity, in presence of 0.12 mM Cd2+ | Silurus glanis |
| 0.00000004 | - |
liver microsomes, aminopyrene-N-demethylation activity, in presence of 0.12 mM Cd2+ | Cyprinus carpio |
| 0.00000004 | - |
liver microsomes, aminopyrene-N-demethylation activity, in presence of 0.12 mM Cd2+ | Hypophthalmichthys molitrix |
| 0.000000066 | - |
liver microsomes, 7-ethoxyresorufin-O-deethylase activity, in presence of 0.12 mM Cd2+ | Cyprinus carpio |
| 0.00000007 | - |
liver microsomes, 7-ethoxyresorufin-O-deethylase activity, in presence of 0.12 mM Cd2+ | Hypophthalmichthys molitrix |
| 0.00000015 | - |
liver microsomes, 7-ethoxycoumarin-O-deethylase activity, in presence of 0.12 mM Cd2+ | Cyprinus carpio |
| 0.00000257 | - |
liver microsomes, 7-ethoxyresorufin-O-deethylase activity, in absence of Cd2+ | Hypophthalmichthys molitrix |
| 0.00000381 | - |
liver microsomes, 7-ethoxyresorufin-O-deethylase activity, in absence of Cd2+ | Silurus glanis |
| 0.00000385 | - |
liver microsomes, 7-ethoxycoumarin-O-deethylase activity, in absence of Cd2+ | Silurus glanis |
| 0.0000325 | - |
liver microsomes, aminopyrene-N-demethylation activity, in absence of Cd2+ | Silurus glanis |
| 0.0000377 | - |
liver microsomes, 7-ethoxycoumarin-O-deethylase activity, in absence of Cd2+ | Hypophthalmichthys molitrix |
| 0.0002166 | - |
liver microsomes, aminopyrene-N-demethylation activity, in absence of Cd2+ | Hypophthalmichthys molitrix |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 7-ethoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2 | 7-ethoxycoumarin O-deethylation | Cyprinus carpio | ? | - |
? | |
| 7-ethoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2 | 7-ethoxycoumarin O-deethylation | Silurus glanis | ? | - |
? | |
| 7-ethoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2 | 7-ethoxycoumarin O-deethylation | Hypophthalmichthys molitrix | ? | - |
? | |
| 7-ethoxyresorufin + [reduced NADPH-hemoprotein reductase] + O2 | 7-ethoxyresorufin O-deethylation | Cyprinus carpio | ? | - |
? | |
| 7-ethoxyresorufin + [reduced NADPH-hemoprotein reductase] + O2 | 7-ethoxyresorufin O-deethylation | Silurus glanis | ? | - |
? | |
| 7-ethoxyresorufin + [reduced NADPH-hemoprotein reductase] + O2 | 7-ethoxyresorufin O-deethylation | Hypophthalmichthys molitrix | ? | - |
? | |
| aminopyrine + [reduced NADPH-hemoprotein reductase] + O2 | aminopyrene-N-demethylation | Cyprinus carpio | ? + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| aminopyrine + [reduced NADPH-hemoprotein reductase] + O2 | aminopyrene-N-demethylation | Silurus glanis | ? + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| aminopyrine + [reduced NADPH-hemoprotein reductase] + O2 | aminopyrene-N-demethylation | Hypophthalmichthys molitrix | ? + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 7-ethoxycoumarin-O-deethylase | - |
Cyprinus carpio |
| 7-ethoxycoumarin-O-deethylase | - |
Silurus glanis |
| 7-ethoxycoumarin-O-deethylase | - |
Hypophthalmichthys molitrix |
| 7-ethoxyresorufin-O-deethylase | - |
Cyprinus carpio |
| 7-ethoxyresorufin-O-deethylase | - |
Silurus glanis |
| 7-ethoxyresorufin-O-deethylase | - |
Hypophthalmichthys molitrix |
| CYP1A | - |
Cyprinus carpio |
| CYP1A | - |
Silurus glanis |
| CYP1A | - |
Hypophthalmichthys molitrix |
| Cyt P450 | - |
Cyprinus carpio |
| Cyt P450 | - |
Silurus glanis |
| Cyt P450 | - |
Hypophthalmichthys molitrix |
| cytochrome P450 monooxygenase | - |
Cyprinus carpio |
| cytochrome P450 monooxygenase | - |
Silurus glanis |
| cytochrome P450 monooxygenase | - |
Hypophthalmichthys molitrix |
| ECOD | - |
Cyprinus carpio |
| ECOD | - |
Silurus glanis |
| ECOD | - |
Hypophthalmichthys molitrix |
| EROD | - |
Cyprinus carpio |
| EROD | - |
Silurus glanis |
| EROD | - |
Hypophthalmichthys molitrix |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Cyprinus carpio |
| 30 | - |
assay at | Silurus glanis |
| 30 | - |
assay at | Hypophthalmichthys molitrix |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Cyprinus carpio |
| 7.4 | - |
assay at | Silurus glanis |
| 7.4 | - |
assay at | Hypophthalmichthys molitrix |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Cyprinus carpio | |
| NADPH | - |
Silurus glanis | |
| NADPH | - |
Hypophthalmichthys molitrix | |
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