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show all sequences of 1.14.14.1

Cytochrome P450 monooxygenase as a tool for metabolizing of herbicides in plants

Gorinova, N.; Nedkovska, M.; Atanassov, A.; Biotechnol. Biotechnol. Equip. 19, 105-115 (2005)
No PubMed abstract available

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
additional information
chlorotoluron metabolism in sensitive plants is induced by blue light, induction of P450 in wounded tissues, all plant P450s depend on NADPH-cytochrome P450 reductase for providing the reducing equivalents needed to activate molecular oxygen, induction of the enzyme by light due to coupling of P450 monooxygenase to photosynthetic electron transfer systems in chloroplasts, overview
Lolium rigidum
additional information
induction of P450 in wounded tissues, all plant P450s depend on NADPH-cytochrome P450 reductase for providing the reducing equivalents needed to activate molecular oxygen, induction of the enzyme by light due to coupling of P450 monooxygenase to photosynthetic electron transfer systems in chloroplasts, overview
Nicotiana tabacum
additional information
induction of P450 in wounded tissues, all plant P450s depend on NADPH-cytochrome P450 reductase for providing the reducing equivalents needed to activate molecular oxygen, induction of the enzyme by light due to coupling of P450 monooxygenase to photosynthetic electron transfer systems in chloroplasts, overview
Phelipanche ramosa
additional information
induction of P450 in wounded tissues, all plant P450s depend on NADPH-cytochrome P450 reductase for providing the reducing equivalents needed to activate molecular oxygen, induction of the enzyme by light due to coupling of P450 monooxygenase to photosynthetic electron transfer systems in chloroplasts, overview
Solanum tuberosum
additional information
induction of P450 in wounded tissues, all plant P450s depend on NADPH-cytochrome P450 reductase for providing the reducing equivalents needed to activate molecular oxygen, induction of the enzyme by light due to coupling of P450 monooxygenase to photosynthetic electron transfer systems in chloroplasts, overview
Sorghum sp.
additional information
induction of P450 in wounded tissues, all plant P450s depend on NADPH-cytochrome P450 reductase for providing the reducing equivalents needed to activate molecular oxygen, induction of the enzyme by light due to coupling of P450 monooxygenase to photosynthetic electron transfer systems in chloroplasts, overview
Triticum aestivum
additional information
induction of P450 in wounded tissues, all plant P450s depend on NADPH-cytochrome P450 reductase for providing the reducing equivalents needed to activate molecular oxygen, induction of the enzyme by light due to coupling of P450 monooxygenase to photosynthetic electron transfer systems in chloroplasts, overview
Zea mays
Application
Application
Commentary
Organism
agriculture
cytochrome P450 monooxygenase as a tool for metabolizing of herbicides in plants
Nicotiana tabacum
agriculture
cytochrome P450 monooxygenase as a tool for metabolizing of herbicides in plants
Solanum tuberosum
agriculture
the enzyme is of great importance commercially not only from the point of view of herbicide resistance but also in terms of ecotoxicology
Triticum aestivum
agriculture
the enzyme is of great importance commercially not only from the point of view of herbicide resistance but also in terms of ecotoxicology
Zea mays
biotechnology
cytochrome P450 monooxygenase as a tool for metabolizing of herbicides in plants
Nicotiana tabacum
biotechnology
cytochrome P450 monooxygenase as a tool for metabolizing of herbicides in plants
Solanum tuberosum
environmental protection
the enzyme is of great importance commercially not only from the point of view of herbicide resistance but also in terms of ecotoxicology
Triticum aestivum
environmental protection
the enzyme is of great importance commercially not only from the point of view of herbicide resistance but also in terms of ecotoxicology
Zea mays
additional information
the use of genetically engineered herbicide resistant plants is one of the most effective ways for broomrape control, since the parasitic plant damages the agriculturally important tobacco plants in Bulgaria, overview
Phelipanche ramosa
Cloned(Commentary)
Commentary
Organism
expression of recombinant human P4502B6 and yeast reductase fused enzyme in transgenic tobacco plants, integration into the tobacco genome, functional expression of CYP1A1 and CYP1A1-yeast reductase fused enzyme in transgenic potato plants, genetic transformation is mediated by Agrobacterium tumefaciens
Homo sapiens
functional expression of the fused enzyme between rat CYP1A1 and rat or yeast reductase in transgenic tobacco and potato plants mainly in microsomes
Rattus norvegicus
Engineering
Amino acid exchange
Commentary
Organism
additional information
transgenic tobacco plants expressing rat CYP1A1 and its fused enzyme with yeast reductase showed tolerance to the herbicide chlorotoluron, some of them are tolerant to the herbicides diuron and atrazine, the transgenic plants also show increased activity against 7-ethoxycoumarin, overview
Nicotiana tabacum
additional information
the herbicide chlorotoluron delayed the germination and development of Orobanche ramosa seeds in case of use of transgenic plants tolerant to the herbicide
Phelipanche ramosa
additional information
construction of a fused enzyme between rat CYP1A1 and rat reductase on microsomes in the recombinant yeast cells, which showed enhanced specific activity as compared with the original enzyme system
Rattus norvegicus
additional information
transgenic potato plants expressing CYP1A1 and its fused enzyme with yeast reductase showed tolerance to the herbicide chlorotoluron, some of them are tolerant to the herbicides diuron and atrazine, the transgenic plants also show increased activity against 7-ethoxycoumarin, overview
Solanum tuberosum
Inhibitors
Inhibitors
Commentary
Organism
Structure
Atrazine
a herbicide
Nicotiana tabacum
Atrazine
a herbicide
Solanum tuberosum
chlorotoluron
metabolism in sensitive plants is induced by blue light
Lolium rigidum
chlorotoluron
a herbicide
Nicotiana tabacum
chlorotoluron
chlorotoluron treatment of the transgenic plants could lead to inhibition of the germination of broomrape, overview
Phelipanche ramosa
chlorotoluron
a herbicide
Solanum tuberosum
Diuron
a herbicide
Nicotiana tabacum
Diuron
a herbicide
Solanum tuberosum
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
membrane-bound
Homo sapiens
-
-
microsome
membrane-bound
Lolium rigidum
-
-
microsome
membrane-bound
Nicotiana tabacum
-
-
microsome
membrane-bound
Phelipanche ramosa
-
-
microsome
membrane-bound
Rattus norvegicus
-
-
microsome
membrane-bound
Solanum tuberosum
-
-
microsome
membrane-bound
Sorghum sp.
-
-
microsome
membrane-bound
Triticum aestivum
-
-
microsome
membrane-bound
Zea mays
-
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Fe2+
heme iron
Homo sapiens
Fe2+
heme iron
Lolium rigidum
Fe2+
heme iron
Nicotiana tabacum
Fe2+
heme iron
Phelipanche ramosa
Fe2+
heme iron
Rattus norvegicus
Fe2+
heme iron
Solanum tuberosum
Fe2+
heme iron
Sorghum sp.
Fe2+
heme iron
Triticum aestivum
Fe2+
heme iron
Zea mays
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
7-ethoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2
Rattus norvegicus
wild-type enzyme and recombinant enzyme CYP1A1 fused to yeast reductase and expressed in transgenic tobacco plants
7-hydroxycoumarin + [oxidized NADPH-hemoprotein reductase] + H2O + ?
-
-
?
7-ethoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2
Homo sapiens
wild-type enzyme and recombinant enzyme P4502B6 fused to yeast reductase and expressed in transgenic tobacco plants
7-hydroxycoumarin + [oxidized NADPH-hemoprotein reductase] + H2O + ?
-
-
?
bentazon + [reduced NADPH-hemoprotein reductase] + O2
Zea mays
ring-hydroxylation
?
-
-
?
benzo-pyrene + [reduced NADPH-hemoprotein reductase] + O2
Rattus norvegicus
recombinant enzyme CYP1A1 fused to yeast reductase and expressed in transgenic tobacco plants
?
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
Triticum aestivum
a combination of oxidative N-demethylation and hydroxylation of the ring-methyl group
?
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
Solanum tuberosum
a combination of oxidative N-demethylation and hydroxylation of the ring-methyl group
?
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
Nicotiana tabacum
a combination of oxidative N-demethylation and hydroxylation of the ring-methyl group
?
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
Rattus norvegicus
a combination of oxidative N-demethylation and hydroxylation of the ring-methyl group, recombinant enzyme CYP1A1 fused to yeast reductase and expressed in transgenic tobacco plants
?
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
Homo sapiens
recombinant wild-type enzyme and enzyme mutant fused to yeast reductase expressed in transgenic potato plants
?
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
Zea mays
ring methyl-hydroxylation
?
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
Lolium rigidum
ring methyl-hydroxylation
?
-
-
?
diclofop + [reduced NADPH-hemoprotein reductase] + O2
Triticum aestivum
ring-hydroxylation
?
-
-
?
metolachlor + [reduced NADPH-hemoprotein reductase] + O2
Sorghum sp.
de-ethylation
?
-
-
?
additional information
Triticum aestivum
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
?
-
-
-
additional information
Zea mays
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
?
-
-
-
additional information
Solanum tuberosum
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
?
-
-
-
additional information
Nicotiana tabacum
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
?
-
-
-
additional information
Sorghum sp.
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
?
-
-
-
additional information
Phelipanche ramosa
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
?
-
-
-
additional information
Lolium rigidum
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Lolium rigidum
-
-
-
Nicotiana tabacum
-
-
-
Phelipanche ramosa
-
broomrape, a root parasitic weed often in tobacco plants
-
Rattus norvegicus
-
-
-
Solanum tuberosum
-
-
-
Sorghum sp.
-
-
-
Triticum aestivum
-
-
-
Zea mays
-
-
-
Reaction
Reaction
Commentary
Organism
RH + [reduced NADPH-hemoprotein reductase] + O2 = ROH + [oxidized NADPH-hemoprotein reductase] + H2O
reaction mechanism
Lolium rigidum
RH + [reduced NADPH-hemoprotein reductase] + O2 = ROH + [oxidized NADPH-hemoprotein reductase] + H2O
reaction mechanism
Nicotiana tabacum
RH + [reduced NADPH-hemoprotein reductase] + O2 = ROH + [oxidized NADPH-hemoprotein reductase] + H2O
reaction mechanism
Phelipanche ramosa
RH + [reduced NADPH-hemoprotein reductase] + O2 = ROH + [oxidized NADPH-hemoprotein reductase] + H2O
reaction mechanism
Solanum tuberosum
RH + [reduced NADPH-hemoprotein reductase] + O2 = ROH + [oxidized NADPH-hemoprotein reductase] + H2O
reaction mechanism
Sorghum sp.
RH + [reduced NADPH-hemoprotein reductase] + O2 = ROH + [oxidized NADPH-hemoprotein reductase] + H2O
reaction mechanism
Triticum aestivum
RH + [reduced NADPH-hemoprotein reductase] + O2 = ROH + [oxidized NADPH-hemoprotein reductase] + H2O
reaction mechanism
Zea mays
Source Tissue
Source Tissue
Commentary
Organism
Textmining
seed
-
Phelipanche ramosa
-
seed
-
Sorghum sp.
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
7-ethoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2
wild-type enzyme and recombinant enzyme CYP1A1 fused to yeast reductase and expressed in transgenic tobacco plants
672721
Rattus norvegicus
7-hydroxycoumarin + [oxidized NADPH-hemoprotein reductase] + H2O + ?
-
-
-
?
7-ethoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2
wild-type enzyme and recombinant enzyme P4502B6 fused to yeast reductase and expressed in transgenic tobacco plants
672721
Homo sapiens
7-hydroxycoumarin + [oxidized NADPH-hemoprotein reductase] + H2O + ?
-
-
-
?
bentazon + [reduced NADPH-hemoprotein reductase] + O2
ring-hydroxylation
672721
Zea mays
?
-
-
-
?
benzo-pyrene + [reduced NADPH-hemoprotein reductase] + O2
recombinant enzyme CYP1A1 fused to yeast reductase and expressed in transgenic tobacco plants
672721
Rattus norvegicus
?
-
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
a combination of oxidative N-demethylation and hydroxylation of the ring-methyl group
672721
Triticum aestivum
?
-
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
a combination of oxidative N-demethylation and hydroxylation of the ring-methyl group
672721
Solanum tuberosum
?
-
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
a combination of oxidative N-demethylation and hydroxylation of the ring-methyl group
672721
Nicotiana tabacum
?
-
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
a combination of oxidative N-demethylation and hydroxylation of the ring-methyl group, recombinant enzyme CYP1A1 fused to yeast reductase and expressed in transgenic tobacco plants
672721
Rattus norvegicus
?
-
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
recombinant wild-type enzyme and enzyme mutant fused to yeast reductase expressed in transgenic potato plants
672721
Homo sapiens
?
-
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
ring methyl-hydroxylation
672721
Zea mays
?
-
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
ring methyl-hydroxylation
672721
Lolium rigidum
?
-
-
-
?
diclofop + [reduced NADPH-hemoprotein reductase] + O2
ring-hydroxylation
672721
Triticum aestivum
?
-
-
-
?
metolachlor + [reduced NADPH-hemoprotein reductase] + O2
de-ethylation
672721
Sorghum sp.
?
-
-
-
?
additional information
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
672721
Triticum aestivum
?
-
-
-
-
additional information
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
672721
Zea mays
?
-
-
-
-
additional information
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
672721
Solanum tuberosum
?
-
-
-
-
additional information
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
672721
Nicotiana tabacum
?
-
-
-
-
additional information
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
672721
Sorghum sp.
?
-
-
-
-
additional information
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
672721
Phelipanche ramosa
?
-
-
-
-
additional information
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
672721
Lolium rigidum
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
More
the enzyme is a membrane-bound heme protein, that consists of a protoporphyrin IX and an apoprotein, which confers the substrate specificity
Lolium rigidum
More
the enzyme is a membrane-bound heme protein, that consists of a protoporphyrin IX and an apoprotein, which confers the substrate specificity
Nicotiana tabacum
More
the enzyme is a membrane-bound heme protein, that consists of a protoporphyrin IX and an apoprotein, which confers the substrate specificity
Phelipanche ramosa
More
the enzyme is a membrane-bound heme protein, that consists of a protoporphyrin IX and an apoprotein, which confers the substrate specificity
Solanum tuberosum
More
the enzyme is a membrane-bound heme protein, that consists of a protoporphyrin IX and an apoprotein, which confers the substrate specificity
Sorghum sp.
More
the enzyme is a membrane-bound heme protein, that consists of a protoporphyrin IX and an apoprotein, which confers the substrate specificity
Triticum aestivum
More
the enzyme is a membrane-bound heme protein, that consists of a protoporphyrin IX and an apoprotein, which confers the substrate specificity
Zea mays
Cofactor
Cofactor
Commentary
Organism
Structure
FAD
-
Lolium rigidum
FAD
-
Nicotiana tabacum
FAD
-
Phelipanche ramosa
FAD
-
Rattus norvegicus
FAD
-
Solanum tuberosum
FAD
-
Sorghum sp.
FAD
-
Triticum aestivum
FAD
-
Zea mays
FAD
-
Homo sapiens
NADPH
-
Lolium rigidum
NADPH
-
Nicotiana tabacum
NADPH
-
Phelipanche ramosa
NADPH
-
Solanum tuberosum
NADPH
-
Sorghum sp.
NADPH
-
Triticum aestivum
NADPH
-
Zea mays
NADPH
-
Homo sapiens
NADPH
-
Rattus norvegicus
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
additional information
chlorotoluron metabolism in sensitive plants is induced by blue light, induction of P450 in wounded tissues, all plant P450s depend on NADPH-cytochrome P450 reductase for providing the reducing equivalents needed to activate molecular oxygen, induction of the enzyme by light due to coupling of P450 monooxygenase to photosynthetic electron transfer systems in chloroplasts, overview
Lolium rigidum
additional information
induction of P450 in wounded tissues, all plant P450s depend on NADPH-cytochrome P450 reductase for providing the reducing equivalents needed to activate molecular oxygen, induction of the enzyme by light due to coupling of P450 monooxygenase to photosynthetic electron transfer systems in chloroplasts, overview
Nicotiana tabacum
additional information
induction of P450 in wounded tissues, all plant P450s depend on NADPH-cytochrome P450 reductase for providing the reducing equivalents needed to activate molecular oxygen, induction of the enzyme by light due to coupling of P450 monooxygenase to photosynthetic electron transfer systems in chloroplasts, overview
Phelipanche ramosa
additional information
induction of P450 in wounded tissues, all plant P450s depend on NADPH-cytochrome P450 reductase for providing the reducing equivalents needed to activate molecular oxygen, induction of the enzyme by light due to coupling of P450 monooxygenase to photosynthetic electron transfer systems in chloroplasts, overview
Solanum tuberosum
additional information
induction of P450 in wounded tissues, all plant P450s depend on NADPH-cytochrome P450 reductase for providing the reducing equivalents needed to activate molecular oxygen, induction of the enzyme by light due to coupling of P450 monooxygenase to photosynthetic electron transfer systems in chloroplasts, overview
Sorghum sp.
additional information
induction of P450 in wounded tissues, all plant P450s depend on NADPH-cytochrome P450 reductase for providing the reducing equivalents needed to activate molecular oxygen, induction of the enzyme by light due to coupling of P450 monooxygenase to photosynthetic electron transfer systems in chloroplasts, overview
Triticum aestivum
additional information
induction of P450 in wounded tissues, all plant P450s depend on NADPH-cytochrome P450 reductase for providing the reducing equivalents needed to activate molecular oxygen, induction of the enzyme by light due to coupling of P450 monooxygenase to photosynthetic electron transfer systems in chloroplasts, overview
Zea mays
Application (protein specific)
Application
Commentary
Organism
agriculture
cytochrome P450 monooxygenase as a tool for metabolizing of herbicides in plants
Nicotiana tabacum
agriculture
cytochrome P450 monooxygenase as a tool for metabolizing of herbicides in plants
Solanum tuberosum
agriculture
the enzyme is of great importance commercially not only from the point of view of herbicide resistance but also in terms of ecotoxicology
Triticum aestivum
agriculture
the enzyme is of great importance commercially not only from the point of view of herbicide resistance but also in terms of ecotoxicology
Zea mays
biotechnology
cytochrome P450 monooxygenase as a tool for metabolizing of herbicides in plants
Nicotiana tabacum
biotechnology
cytochrome P450 monooxygenase as a tool for metabolizing of herbicides in plants
Solanum tuberosum
environmental protection
the enzyme is of great importance commercially not only from the point of view of herbicide resistance but also in terms of ecotoxicology
Triticum aestivum
environmental protection
the enzyme is of great importance commercially not only from the point of view of herbicide resistance but also in terms of ecotoxicology
Zea mays
additional information
the use of genetically engineered herbicide resistant plants is one of the most effective ways for broomrape control, since the parasitic plant damages the agriculturally important tobacco plants in Bulgaria, overview
Phelipanche ramosa
Cloned(Commentary) (protein specific)
Commentary
Organism
expression of recombinant human P4502B6 and yeast reductase fused enzyme in transgenic tobacco plants, integration into the tobacco genome, functional expression of CYP1A1 and CYP1A1-yeast reductase fused enzyme in transgenic potato plants, genetic transformation is mediated by Agrobacterium tumefaciens
Homo sapiens
functional expression of the fused enzyme between rat CYP1A1 and rat or yeast reductase in transgenic tobacco and potato plants mainly in microsomes
Rattus norvegicus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
FAD
-
Lolium rigidum
FAD
-
Nicotiana tabacum
FAD
-
Phelipanche ramosa
FAD
-
Rattus norvegicus
FAD
-
Solanum tuberosum
FAD
-
Sorghum sp.
FAD
-
Triticum aestivum
FAD
-
Zea mays
FAD
-
Homo sapiens
NADPH
-
Lolium rigidum
NADPH
-
Nicotiana tabacum
NADPH
-
Phelipanche ramosa
NADPH
-
Solanum tuberosum
NADPH
-
Sorghum sp.
NADPH
-
Triticum aestivum
NADPH
-
Zea mays
NADPH
-
Homo sapiens
NADPH
-
Rattus norvegicus
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
additional information
transgenic tobacco plants expressing rat CYP1A1 and its fused enzyme with yeast reductase showed tolerance to the herbicide chlorotoluron, some of them are tolerant to the herbicides diuron and atrazine, the transgenic plants also show increased activity against 7-ethoxycoumarin, overview
Nicotiana tabacum
additional information
the herbicide chlorotoluron delayed the germination and development of Orobanche ramosa seeds in case of use of transgenic plants tolerant to the herbicide
Phelipanche ramosa
additional information
construction of a fused enzyme between rat CYP1A1 and rat reductase on microsomes in the recombinant yeast cells, which showed enhanced specific activity as compared with the original enzyme system
Rattus norvegicus
additional information
transgenic potato plants expressing CYP1A1 and its fused enzyme with yeast reductase showed tolerance to the herbicide chlorotoluron, some of them are tolerant to the herbicides diuron and atrazine, the transgenic plants also show increased activity against 7-ethoxycoumarin, overview
Solanum tuberosum
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Atrazine
a herbicide
Nicotiana tabacum
Atrazine
a herbicide
Solanum tuberosum
chlorotoluron
metabolism in sensitive plants is induced by blue light
Lolium rigidum
chlorotoluron
a herbicide
Nicotiana tabacum
chlorotoluron
chlorotoluron treatment of the transgenic plants could lead to inhibition of the germination of broomrape, overview
Phelipanche ramosa
chlorotoluron
a herbicide
Solanum tuberosum
Diuron
a herbicide
Nicotiana tabacum
Diuron
a herbicide
Solanum tuberosum
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
membrane-bound
Homo sapiens
-
-
microsome
membrane-bound
Lolium rigidum
-
-
microsome
membrane-bound
Nicotiana tabacum
-
-
microsome
membrane-bound
Phelipanche ramosa
-
-
microsome
membrane-bound
Rattus norvegicus
-
-
microsome
membrane-bound
Solanum tuberosum
-
-
microsome
membrane-bound
Sorghum sp.
-
-
microsome
membrane-bound
Triticum aestivum
-
-
microsome
membrane-bound
Zea mays
-
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Fe2+
heme iron
Homo sapiens
Fe2+
heme iron
Lolium rigidum
Fe2+
heme iron
Nicotiana tabacum
Fe2+
heme iron
Phelipanche ramosa
Fe2+
heme iron
Rattus norvegicus
Fe2+
heme iron
Solanum tuberosum
Fe2+
heme iron
Sorghum sp.
Fe2+
heme iron
Triticum aestivum
Fe2+
heme iron
Zea mays
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
7-ethoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2
Rattus norvegicus
wild-type enzyme and recombinant enzyme CYP1A1 fused to yeast reductase and expressed in transgenic tobacco plants
7-hydroxycoumarin + [oxidized NADPH-hemoprotein reductase] + H2O + ?
-
-
?
7-ethoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2
Homo sapiens
wild-type enzyme and recombinant enzyme P4502B6 fused to yeast reductase and expressed in transgenic tobacco plants
7-hydroxycoumarin + [oxidized NADPH-hemoprotein reductase] + H2O + ?
-
-
?
bentazon + [reduced NADPH-hemoprotein reductase] + O2
Zea mays
ring-hydroxylation
?
-
-
?
benzo-pyrene + [reduced NADPH-hemoprotein reductase] + O2
Rattus norvegicus
recombinant enzyme CYP1A1 fused to yeast reductase and expressed in transgenic tobacco plants
?
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
Triticum aestivum
a combination of oxidative N-demethylation and hydroxylation of the ring-methyl group
?
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
Solanum tuberosum
a combination of oxidative N-demethylation and hydroxylation of the ring-methyl group
?
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
Nicotiana tabacum
a combination of oxidative N-demethylation and hydroxylation of the ring-methyl group
?
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
Rattus norvegicus
a combination of oxidative N-demethylation and hydroxylation of the ring-methyl group, recombinant enzyme CYP1A1 fused to yeast reductase and expressed in transgenic tobacco plants
?
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
Homo sapiens
recombinant wild-type enzyme and enzyme mutant fused to yeast reductase expressed in transgenic potato plants
?
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
Zea mays
ring methyl-hydroxylation
?
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
Lolium rigidum
ring methyl-hydroxylation
?
-
-
?
diclofop + [reduced NADPH-hemoprotein reductase] + O2
Triticum aestivum
ring-hydroxylation
?
-
-
?
metolachlor + [reduced NADPH-hemoprotein reductase] + O2
Sorghum sp.
de-ethylation
?
-
-
?
additional information
Triticum aestivum
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
?
-
-
-
additional information
Zea mays
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
?
-
-
-
additional information
Solanum tuberosum
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
?
-
-
-
additional information
Nicotiana tabacum
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
?
-
-
-
additional information
Sorghum sp.
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
?
-
-
-
additional information
Phelipanche ramosa
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
?
-
-
-
additional information
Lolium rigidum
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
seed
-
Phelipanche ramosa
-
seed
-
Sorghum sp.
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
7-ethoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2
wild-type enzyme and recombinant enzyme CYP1A1 fused to yeast reductase and expressed in transgenic tobacco plants
672721
Rattus norvegicus
7-hydroxycoumarin + [oxidized NADPH-hemoprotein reductase] + H2O + ?
-
-
-
?
7-ethoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2
wild-type enzyme and recombinant enzyme P4502B6 fused to yeast reductase and expressed in transgenic tobacco plants
672721
Homo sapiens
7-hydroxycoumarin + [oxidized NADPH-hemoprotein reductase] + H2O + ?
-
-
-
?
bentazon + [reduced NADPH-hemoprotein reductase] + O2
ring-hydroxylation
672721
Zea mays
?
-
-
-
?
benzo-pyrene + [reduced NADPH-hemoprotein reductase] + O2
recombinant enzyme CYP1A1 fused to yeast reductase and expressed in transgenic tobacco plants
672721
Rattus norvegicus
?
-
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
a combination of oxidative N-demethylation and hydroxylation of the ring-methyl group
672721
Triticum aestivum
?
-
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
a combination of oxidative N-demethylation and hydroxylation of the ring-methyl group
672721
Solanum tuberosum
?
-
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
a combination of oxidative N-demethylation and hydroxylation of the ring-methyl group
672721
Nicotiana tabacum
?
-
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
a combination of oxidative N-demethylation and hydroxylation of the ring-methyl group, recombinant enzyme CYP1A1 fused to yeast reductase and expressed in transgenic tobacco plants
672721
Rattus norvegicus
?
-
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
recombinant wild-type enzyme and enzyme mutant fused to yeast reductase expressed in transgenic potato plants
672721
Homo sapiens
?
-
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
ring methyl-hydroxylation
672721
Zea mays
?
-
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
ring methyl-hydroxylation
672721
Lolium rigidum
?
-
-
-
?
diclofop + [reduced NADPH-hemoprotein reductase] + O2
ring-hydroxylation
672721
Triticum aestivum
?
-
-
-
?
metolachlor + [reduced NADPH-hemoprotein reductase] + O2
de-ethylation
672721
Sorghum sp.
?
-
-
-
?
additional information
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
672721
Triticum aestivum
?
-
-
-
-
additional information
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
672721
Zea mays
?
-
-
-
-
additional information
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
672721
Solanum tuberosum
?
-
-
-
-
additional information
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
672721
Nicotiana tabacum
?
-
-
-
-
additional information
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
672721
Sorghum sp.
?
-
-
-
-
additional information
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
672721
Phelipanche ramosa
?
-
-
-
-
additional information
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
672721
Lolium rigidum
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
More
the enzyme is a membrane-bound heme protein, that consists of a protoporphyrin IX and an apoprotein, which confers the substrate specificity
Lolium rigidum
More
the enzyme is a membrane-bound heme protein, that consists of a protoporphyrin IX and an apoprotein, which confers the substrate specificity
Nicotiana tabacum
More
the enzyme is a membrane-bound heme protein, that consists of a protoporphyrin IX and an apoprotein, which confers the substrate specificity
Phelipanche ramosa
More
the enzyme is a membrane-bound heme protein, that consists of a protoporphyrin IX and an apoprotein, which confers the substrate specificity
Solanum tuberosum
More
the enzyme is a membrane-bound heme protein, that consists of a protoporphyrin IX and an apoprotein, which confers the substrate specificity
Sorghum sp.
More
the enzyme is a membrane-bound heme protein, that consists of a protoporphyrin IX and an apoprotein, which confers the substrate specificity
Triticum aestivum
More
the enzyme is a membrane-bound heme protein, that consists of a protoporphyrin IX and an apoprotein, which confers the substrate specificity
Zea mays
Other publictions for EC 1.14.14.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
744431
Matowane
In silico analysis of cytochr ...
Sporothrix schenckii, Sporothrix schenckii ATCC 58251
Biochim. Biophys. Acta
1866
166-177
2018
-
-
-
1
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6
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2
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1
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1
1
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-
2
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
746324
Hasegawa
Cytochrome P450 monooxygenase ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
114
E7545-E7553
2017
-
1
-
-
-
-
-
-
-
-
-
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3
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1
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-
-
1
1
-
-
-
744184
Kolrep
Differences in metabolism of ...
Homo sapiens, Rattus norvegicus
Arch. Toxicol.
90
2025-2036
2016
-
-
2
-
-
-
2
-
-
-
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-
-
5
-
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3
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3
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3
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3
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-
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-
-
-
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-
-
-
2
3
-
-
-
745019
Wriessnegger
Enhancing cytochrome P450-med ...
Homo sapiens
Fungal Genet. Biol.
89
114-125
2016
1
-
1
-
-
-
-
-
-
-
-
-
-
4
-
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1
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1
1
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-
-
-
-
744697
Yin
Unusually broad substrate pro ...
Labrenzia aggregata, Labrenzia aggregata DSM 13394
ChemBioChem
15
2443-2449
2014
-
-
1
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
19
1
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-
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-
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5
-
-
-
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-
1
5
-
-
-
-
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-
-
-
19
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
745417
Lee
Production of bioactive hydro ...
Saccharothrix espanaensis
J. Biotechnol.
176
11-17
2014
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
7
-
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-
-
-
-
-
-
-
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-
-
1
1
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
745559
Tosstorff
-
Mediated electron transfer wi ...
Bacillus megaterium, Bacillus megaterium DSM 32
J. Mol. Catal. B
108
51-58
2014
-
1
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
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-
-
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-
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1
1
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-
1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
746534
Lavado
Evaluation of the stereoselec ...
Homo sapiens
Toxicol. Lett.
226
192-197
2014
-
1
-
-
-
-
1
8
-
-
-
-
-
2
-
-
-
-
-
1
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
8
-
-
-
-
-
-
-
-
-
1
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
726736
Syed
CYP63A2, a catalytically versa ...
Phanerochaete chrysosporium
Appl. Environ. Microbiol.
79
2692-2702
2013
-
-
1
-
-
-
-
-
-
-
-
-
-
2
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-
-
-
-
-
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6
-
-
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-
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-
1
-
-
-
-
-
-
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-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
728729
Syed
Rational engineering of the fu ...
Phanerochaete chrysosporium
Protein Eng.
26
553-557
2013
-
-
1
-
5
-
-
-
-
-
-
-
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1
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2
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1
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5
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2
-
-
-
-
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-
-
-
-
-
-
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-
726823
Wang
The involvement of cytochrome ...
Drosophila melanogaster
Arch. Insect Biochem. Physiol.
79
264-275
2012
1
-
-
-
-
-
-
-
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1
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4
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2
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1
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2
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1
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1
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1
-
-
726832
Ide
Molecular identification and f ...
Postia placenta, Postia placenta MAD-698
Arch. Microbiol.
194
243-253
2012
-
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1
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-
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6
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1
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6
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1
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1
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6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
727589
Misra
Characterization of cytochrome ...
Artemisia annua
Gene
510
193-201
2012
-
-
1
-
-
-
-
-
-
-
-
1
-
3
-
-
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-
-
3
-
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5
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1
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1
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-
3
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
712253
Zocher
Structural fine-tuning of a mu ...
Streptomyces thioluteus
J. Am. Chem. Soc.
133
2292-2302
2011
-
-
-
1
1
-
1
-
-
1
-
1
-
1
-
-
-
-
-
-
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2
1
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-
-
-
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1
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1
1
1
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1
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1
-
1
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-
-
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-
2
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
713071
Brignac-Huber
Organization of NADPH-cytochro ...
Oryctolagus cuniculus
Mol. Pharmacol.
79
549-557
2011
-
-
-
-
-
-
-
-
2
1
-
-
-
2
-
-
1
-
-
1
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3
-
1
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1
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2
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2
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2
1
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1
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1
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3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
726753
Schallmey
Characterization of cytochrome ...
Thermobifida fusca
Appl. Microbiol. Biotechnol.
89
1475-1485
2011
-
-
1
-
-
-
-
-
-
-
1
-
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4
-
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1
-
-
-
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13
1
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1
-
-
-
-
-
-
-
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1
-
-
-
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-
-
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1
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1
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13
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
728324
Lah
The versatility of the fungal ...
Curvularia lunata
Mol. Microbiol.
81
1374-1389
2011
-
-
1
-
-
-
-
-
-
-
-
1
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4
-
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-
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5
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1
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1
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5
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
701865
Zhang
Sequence analysis and heterolo ...
Rhodococcus sp.
Appl. Microbiol. Biotechnol.
85
615-624
2010
-
1
1
-
-
-
1
-
-
1
1
-
-
4
-
-
1
-
-
-
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7
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1
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1
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1
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1
1
3
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1
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1
1
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1
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7
-
1
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1
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1
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703483
Liu
Human cytochrome P450 2E1 and ...
Homo sapiens
Environ. Mol. Mutagen.
51
23-30
2010
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1
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1
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3
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1
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1
1
1
1
-
-
704714
Chen
Scanning chimeragenesis: the a ...
Bacillus megaterium
J. Biol. Inorg. Chem.
15
159-174
2010
-
1
1
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1
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7
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1
1
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7
-
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1
-
-
-
-
-
-
-
-
-
-
710821
Nayeem
Modulation by salt intake of t ...
Homo sapiens, Mus musculus, Rattus norvegicus
Am. J. Physiol. Regul. Integr. Comp. Physiol.
299
R325-R333
2010
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-
-
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3
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3
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3
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6
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21
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3
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3
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3
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6
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21
-
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-
-
-
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-
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3
3
-
-
-
710938
Lamb
Streptomyces coelicolor A3(2) ...
Streptomyces coelicolor, Streptomyces coelicolor A3(2)
Appl. Environ. Microbiol.
76
1975-1980
2010
-
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1
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46
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1
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11
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1
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11
-
-
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-
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-
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1
1
-
-
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711114
Flueck
Reduction in hepatic drug meta ...
Homo sapiens
Biochem. Biophys. Res. Commun.
401
149-153
2010
1
-
1
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1
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1
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1
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2
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2
-
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1
1
1
1
-
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711488
Zhang
Improved expression of recombi ...
Rhodococcus sp.
Bioprocess Biosyst. Eng.
33
1043-1049
2010
-
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1
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1
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4
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1
2
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1
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6
-
1
1
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1
1
-
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-
711544
Liu
Engineering cytochrome P450 mo ...
Rhodococcus ruber
Biotechnol. Lett.
32
841-845
2010
-
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1
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3
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1
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3
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2
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3
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1
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1
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1
1
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-
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712306
Tischler
StyA1 and StyA2B from Rhodococ ...
Pseudomonas sp., Pseudomonas sp. VLB120
J. Bacteriol.
192
5220-5227
2010
1
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1
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4
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11
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1
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1
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5
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13
1
1
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1
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2
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1
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1
2
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4
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1
1
-
5
-
13
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
713083
Platt
Fruits and vegetables protect ...
Homo sapiens
Mutat. Res.
703
90-98
2010
-
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1
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1
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1
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24
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3
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1
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1
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1
1
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1
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1
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3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
698017
Liu
Aromatase (P450arom) and 11bet ...
Monopterus albus
Fish Physiol. Biochem.
35
511-518
2009
-
-
1
-
-
-
-
-
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1
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4
-
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4
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1
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1
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1
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4
-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701804
Subramanian
Role of P450 monooxygenases in ...
Phanerochaete chrysosporium, Phanerochaete chrysosporium BKM-F-1767
Appl. Environ. Microbiol.
75
5570-5580
2009
-
-
-
-
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1
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11
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2
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1
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-
-
2
-
-
-
-
-
-
-
-
-
2
1
1
2
-
-
703164
Pekthong
Effects of Andrographis panicu ...
Homo sapiens, Rattus norvegicus
Chem. Biol. Interact.
179
247-255
2009
-
-
-
-
-
-
-
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2
-
-
-
-
10
-
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8
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8
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1
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2
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6
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12
-
-
8
-
-
-
-
-
-
-
-
-
4
-
-
11
-
-
703178
Robin
Engineering and improvement of ...
synthetic construct
Chem. Commun. (Camb. )
0
2478-2480
2009
1
-
1
-
-
-
-
-
-
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2
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1
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1
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1
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-
1
-
1
1
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-
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-
-
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-
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1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
704174
Wright
A suite of activity-based prob ...
Homo sapiens
J. Am. Chem. Soc.
131
10692-10700
2009
1
-
1
-
-
-
4
-
1
-
-
-
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3
-
-
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-
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1
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1
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-
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-
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1
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2
1
-
1
1
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-
-
2
4
-
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1
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-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
704856
Tam
Actions of ethnobotanically se ...
Homo sapiens
J. Ethnopharmacol.
126
119-126
2009
-
1
1
-
-
-
8
-
-
-
-
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12
-
-
-
-
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-
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9
-
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1
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2
7
7
-
-
-
-
18
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-
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-
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
704859
Hardstone
Multiplicative interaction bet ...
Culex quinquefasciatus
J. Evol. Biol.
22
416-423
2009
-
1
-
-
-
-
-
-
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3
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1
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
705804
Acharya
Hepatic CYP3A suppression by h ...
Rattus norvegicus
Mol. Pharmacol.
76
503-515
2009
-
-
-
-
-
-
1
-
1
-
-
-
-
2
-
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1
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-
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-
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-
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-
-
-
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1
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-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
706195
Page
Metabolism of sulphonated anth ...
Apium graveolens, Rheum rhaponticum, Zea mays
Plant Cell Rep.
28
1725-1735
2009
-
1
-
-
-
-
-
-
3
-
-
-
-
7
-
-
-
-
-
6
34
-
15
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
6
34
-
15
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
706309
Pan
Cytochrome P450 monooxygenases ...
Arabidopsis thaliana
Plant Physiol.
150
858-878
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
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-
-
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-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
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-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
706777
Furuya
Phylogenetic analysis of Bacil ...
Bacillus cereus
Steroids
74
906-912
2009
-
-
1
-
-
-
-
-
-
-
-
-
-
10
-
-
-
-
-
-
-
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8
-
-
-
-
-
-
-
-
1
-
-
-
-
-
5
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
706825
Zhang
Sequencing and characterizatio ...
Neovison vison
Toxicol. Appl. Pharmacol.
234
306-313
2009
-
-
1
-
-
-
-
-
1
-
2
-
-
7
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
706841
Beedanagari
Resveratrol inhibits dioxin-in ...
Homo sapiens
Toxicol. Sci.
110
61-67
2009
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
684718
Kranendonk
Impairment of human CYP1A2-med ...
Homo sapiens
Arch. Biochem. Biophys.
475
93-99
2008
-
-
1
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
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1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
686232
Henczova
Effects of Cu(2+) and Pb(2+) o ...
Cyprinus carpio, Hypophthalmichthys molitrix, Silurus glanis
Comp. Biochem. Physiol. C
148
53-60
2008
-
-
-
-
-
-
6
-
3
3
-
-
-
6
-
-
3
-
-
4
3
-
-
-
3
-
-
-
3
-
-
3
-
-
-
-
-
-
3
-
-
-
-
6
-
-
3
3
-
-
-
-
-
3
-
4
3
-
-
-
3
-
-
-
3
-
-
-
-
-
-
-
-
-
693835
Panicco
P450 versus P420: Correlation ...
Bacillus megaterium
J. Phys. Chem. B
112
14063
2008
-
1
-
-
-
-
-
-
-
-
-
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2
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-
-
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695046
Branco
Anchoring effects in a wide bi ...
Bacillus megaterium
Proteins
73
597-607
2008
-
-
1
1
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
13
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
13
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701574
Pachecka
Cytochrome P450 polymorphism-- ...
Homo sapiens
Acta Pol. Pharm.
65
303-306
2008
-
-
-
-
-
-
-
-
2
1
-
-
-
5
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
4
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701835
Dietrich
Cloning, expression and charac ...
Bacillus licheniformis, Bacillus licheniformis DSM 13
Appl. Microbiol. Biotechnol.
79
931-940
2008
-
-
1
-
-
-
1
9
-
-
1
-
-
4
-
-
1
-
-
-
-
-
29
1
-
-
1
9
1
-
1
3
-
-
-
-
-
1
3
-
-
-
-
1
-
9
-
-
1
-
-
-
-
1
-
-
-
-
29
1
-
-
1
9
1
-
1
-
-
-
-
-
-
-
706089
Diczfalusy
4Beta-hydroxycholesterol is a ...
Homo sapiens
Pharmacogenet. Genomics
18
201-208
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
706823
Leoni
The participation of human hep ...
Homo sapiens
Toxicol. Appl. Pharmacol.
233
343-352
2008
-
-
1
-
-
-
5
12
1
-
-
-
-
7
-
-
-
-
-
2
-
-
9
-
-
-
-
-
-
-
-
1
-
-
-
-
-
6
6
-
-
-
-
12
-
12
6
-
-
-
-
-
-
-
-
7
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672654
Vatsyayan
Broad substrate cytochrome P45 ...
Aspergillus terreus, Aspergillus terreus MTCC 6324
Biores. Technol.
99
68-75
2007
-
-
-
-
-
-
-
-
3
1
1
-
-
7
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
3
1
1
-
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671286
Henczova
Detection of toxic effects of ...
Cyprinus carpio, Hypophthalmichthys molitrix, Silurus glanis
Anal. Bioanal. Chem.
385
652-659
2006
5
-
-
-
-
-
3
-
3
-
-
9
-
6
-
-
3
-
-
6
15
-
9
-
3
-
-
-
3
-
-
3
-
-
-
5
-
-
3
-
-
-
-
3
-
-
3
-
-
9
-
-
-
3
-
6
15
-
9
-
3
-
-
-
3
-
-
-
-
-
-
-
-
-
671538
Liu
Cloning, expression, and chara ...
Rhodococcus ruber
Appl. Microbiol. Biotechnol.
72
876-882
2006
-
1
1
-
-
-
-
2
-
1
1
-
-
3
-
-
1
-
-
-
-
-
9
1
1
-
-
2
1
-
-
4
-
-
-
-
1
1
4
-
-
-
-
-
-
2
-
1
1
-
-
-
-
1
-
-
-
-
9
1
1
-
-
2
1
-
-
-
-
-
-
-
-
-
672648
Roccatano
Toward understanding the inact ...
Bacillus megaterium
Biopolymers
83
467-476
2006
-
1
-
-
2
-
-
-
-
1
-
-
2
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
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1
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-
2
-
-
-
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-
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1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673083
Haarmann
Identification of the cytochro ...
Claviceps purpurea, Claviceps purpurea P1
Chembiochem
7
645-652
2006
-
-
1
-
1
-
-
-
-
1
1
4
-
3
-
-
-
-
-
-
-
-
8
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
1
1
4
-
-
-
-
-
-
-
-
8
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673315
Arun
Subcellular/tissue distributio ...
Macrobrachium lamarrei, Macrobrachium malcolmsonii
Ecotoxicology
15
341-346
2006
2
-
-
-
-
-
-
-
6
-
-
2
-
5
-
-
2
-
-
8
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
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6
-
-
2
-
-
-
2
-
8
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673780
Chan
Induction and inhibition of cy ...
Rattus norvegicus
Food Chem. Toxicol.
44
2047-2057
2006
1
-
-
-
-
-
1
-
1
-
-
-
-
2
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
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-
1
1
-
-
-
-
-
-
1
1
-
-
1
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673817
Alvarez
The crtS gene of Xanthophyllom ...
Xanthophyllomyces dendrorhous
Fungal Genet. Biol.
43
261-272
2006
-
-
1
-
1
-
-
-
-
1
-
2
-
4
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
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-
-
-
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1
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-
1
-
-
-
-
-
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1
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674671
Hirao
Effects of restricted feeding ...
Rattus norvegicus
J. Biol. Chem.
281
3165-3171
2006
-
-
1
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
2
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674753
Zhao
Structure of microsomal cytoch ...
Oryctolagus cuniculus
J. Biol. Chem.
281
5973-5981
2006
-
-
1
1
1
-
1
-
1
1
-
-
-
1
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
1
-
-
1
-
-
1
1
-
-
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674972
Eiben
Preparative use of isolated CY ...
Bacillus megaterium, Bacillus subtilis
J. Biotechnol.
124
662-669
2006
-
2
2
1
10
-
1
11
-
2
-
-
-
2
-
-
2
-
-
-
-
-
5
2
-
-
3
20
-
-
-
9
-
-
-
-
2
2
9
1
10
-
-
1
-
11
-
2
-
-
-
-
-
2
-
-
-
-
5
2
-
-
3
20
-
-
-
-
-
-
-
-
-
-
675036
Zeng
Toxicity of aflatoxin B1 to He ...
Helicoverpa zea
J. Chem. Ecol.
32
1459-1471
2006
1
-
-
-
-
-
1
-
-
-
-
1
-
8
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
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-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675947
Ito
Expression of cytochrome P-450 ...
Homo sapiens, Rattus norvegicus
Mol. Cell. Biochem.
284
141-148
2006
-
-
-
-
-
-
-
-
2
-
-
4
-
4
-
-
2
-
-
8
-
-
6
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
4
-
-
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2
-
8
-
-
6
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676430
Zhu
Elongated uppermost internode ...
Oryza sativa
Plant Cell
18
442-456
2006
-
1
1
-
1
-
-
-
1
1
-
2
-
4
-
-
-
-
-
1
-
-
6
-
-
-
-
-
-
-
-
1
-
-
-
-
1
1
1
-
1
-
-
-
-
-
1
1
-
2
-
-
-
-
-
1
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
658959
Hirose
Transgenic rice containing hum ...
Homo sapiens
J. Agric. Food Chem.
53
3461-3467
2005
-
1
-
-
-
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
8
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
8
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671188
Lee
-
Structural diversification of ...
Streptomyces venezuelae
Adv. Synth. Catal.
347
1369-1378
2005
-
-
1
-
1
-
-
-
-
-
-
5
-
1
-
-
1
-
-
-
-
-
8
-
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
5
-
-
-
1
-
-
-
-
8
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
671430
Jungmann
Biocatalytic conversion of ave ...
Streptomyces sp., Streptomyces tubercidicus
Appl. Environ. Microbiol.
71
6968-6976
2005
-
-
2
-
-
-
-
1
-
-
-
2
-
4
-
-
1
-
-
-
1
-
4
-
1
-
-
1
1
-
-
2
-
-
-
-
-
2
2
-
-
-
-
-
-
1
-
-
-
2
-
-
-
1
-
-
1
-
4
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
671725
Johnson
Structural diversity of human ...
Homo sapiens
Biochem. Biophys. Res. Commun.
338
331-336
2005
-
-
1
-
-
-
-
-
2
1
-
3
-
2
-
-
-
1
-
-
-
-
6
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
2
1
-
3
-
-
-
-
-
-
-
-
6
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671729
Cashman
Some distinctions between flav ...
Homo sapiens
Biochem. Biophys. Res. Commun.
338
599-604
2005
1
-
-
-
1
-
2
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
4
1
-
-
1
-
1
-
-
2
-
-
-
1
-
-
2
-
1
-
-
2
-
-
1
-
-
1
-
-
-
-
-
-
-
-
4
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
672721
Gorinova
-
Cytochrome P450 monooxygenase ...
Homo sapiens, Lolium rigidum, Nicotiana tabacum, Phelipanche ramosa, Rattus norvegicus, Solanum tuberosum, Sorghum sp., Triticum aestivum, Zea mays
Biotechnol. Biotechnol. Equip.
19
105-115
2005
7
9
2
-
4
-
8
-
9
9
-
20
-
9
-
-
-
7
-
2
-
-
20
7
-
-
-
-
-
-
-
18
-
-
-
7
9
2
18
-
4
-
-
8
-
-
9
9
-
20
-
-
-
-
-
2
-
-
20
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672802
Doddapaneni
Genome-wide structural and evo ...
Phanerochaete chrysosporium, Phanerochaete chrysosporium BKM-F-1767
BMC Genomics
6
92
2005
-
-
1
-
-
-
-
-
-
-
-
12
-
22
-
-
-
-
-
-
-
-
12
1
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
12
-
-
-
-
-
-
-
-
12
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676306
Yun
-
Cytochrome P-450 monooxygenase ...
Echinochloa phyllopogon
Pestic. Biochem. Physiol.
83
107-114
2005
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676779
Siminszky
Conversion of nicotine to norn ...
Nicotiana tabacum
Proc. Natl. Acad. Sci. USA
102
14919-14924
2005
-
-
1
-
1
-
-
-
1
-
-
2
-
6
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
3
-
-
-
-
-
4
-
-
2
-
-
-
-
-
4
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
658523
Cashman
Effect of total parenteral nut ...
Rattus norvegicus
Drug Metab. Dispos.
32
222-229
2004
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659542
Lentz
Substrate specificity of nativ ...
Bacillus subtilis
J. Biotechnol.
108
41-49
2004
1
-
1
-
3
1
-
6
-
-
-
-
1
3
-
-
-
-
-
-
-
-
10
-
-
-
-
6
-
-
-
-
-
-
-
1
-
1
-
-
3
1
-
-
-
6
-
-
-
-
1
-
-
-
-
-
-
-
10
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
657590
Eschenfeldt
Transformation of fatty acids ...
Candida tropicalis
Appl. Environ. Microbiol.
69
5992-5999
2003
-
-
1
-
-
-
-
4
1
-
-
-
-
3
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660414
Baudry
Molecular docking of substrate ...
Papilio polyxenes
Protein Eng.
16
577-587
2003
-
-
-
1
-
-
-
-
-
-
-
-
-
4
-
-
-
1
-
3
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
658917
Chen
Amino acids in SRS1 and SRS6 a ...
Papilio polyxenes
Insect Mol. Biol.
11
175-186
2002
-
-
-
-
31
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
5
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
31
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660409
Kikuta
Prostaglandin and leukotriene ...
Oryctolagus cuniculus
Prostaglandins
68-69
345-362
2002
-
-
-
-
-
-
-
-
-
-
-
1
-
6
-
-
-
-
-
3
-
-
13
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
13
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
717081
Kobayashi
High-performance liquid chroma ...
Homo sapiens, Rattus norvegicus
Anal. Biochem.
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342-347
2000
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390111
Sevrioukova
Structure of a cytochrome P450 ...
Bacillus megaterium
Proc. Natl. Acad. Sci. USA
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1863-1868
1999
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390110
Oliver
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Engineering the substrate spec ...
Bacillus megaterium
Biochem. J.
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1997
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658319
Gewonyo
Development of a large-scale c ...
Pseudonocardia autotrophica
Biotechnol. Bioeng.
37
1101-1107
1991
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390107
Lang
Structural gene products of th ...
Mus musculus
J. Biol. Chem.
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12058-12067
1981
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390108
Lang
Genetic evidence for many uniq ...
Mus musculus
J. Biol. Chem.
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12068-12075
1981
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390109
Theoharides
Evidence for different hepatic ...
Rattus norvegicus
J. Biol. Chem.
256
2168-2175
1981
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